AI Article Synopsis
- The study examined the relationship between bile reflux (BR) and the composition of microorganisms in gastric juice, involving 50 subjects with various gastric issues.
- Findings showed that different levels of bile acids in gastric juice correlated with changes in microbial diversity, particularly in groups with more severe BR.
- Higher BR levels negatively impacted microbial diversity, and specific bacterial genera were linked to bile acid levels, indicating that BR should be factored into research on gastric microbiomes.
Article Abstract
Background/aims: Bile reflux (BR) can influence the gastric environment by altering gastric acidity and possibly the gastric microbiota composition. This study investigated the correlation between bile acids and microbial compositions in the gastric juice of 50 subjects with differing gastric pathologies.
Methods: This study included 50 subjects, which were categorized into three groups based on the endoscopic BR grading system. The primary and secondary bile acid concentrations in gastric juice samples were measured, and microbiota profiling was conducted using 16 S rRNA gene sequencing.
Results: Significant differences were observed in each bile acid level in the three endoscopic BR groups (P < 0.05). The Shannon index demonstrated a significant decrease in the higher BR groups (P < 0.05). Analysis of the β-diversity revealed that BR significantly altered the gastric microbiota composition. The presence of neoplastic lesions and the presence of H. pylori infection impacted the β-diversity of the gastric juice microbiota. The abundance of the Streptococcus and Lancefielfdella genera exhibited positive correlations for almost all bile acid components(P < 0.05). In addition, the abundance of Slobacterium, Veillonella, and Schaalia showed positive correlations with primary unconjugated bile acids (P < 0.05).
Conclusion: Changes in microbial diversity in the gastric juice were associated with BR presence in the stomach. This result suggests that the degree of BR should be considered when studying the gastric juice microbiome.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11077708 | PMC |
| http://dx.doi.org/10.1186/s13099-024-00619-7 | DOI Listing |
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