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| http://dx.doi.org/10.1038/s41375-024-02274-y | DOI Listing |
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A conifer metabolite corrects episodic ataxia type 1 by voltage sensor-mediated ligand activation of Kv1.1.
Proc Natl Acad Sci U S A
January 2025
Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697.
Loss-of-function sequence variants in , which encodes the voltage-gated potassium channel Kv1.1, cause Episodic Ataxia Type 1 (EA1) and epilepsy. Due to a paucity of drugs that directly rescue mutant Kv1.
View Article and Find Full Text PDFReliable detection of directional couplings using cross-vector measures.
Chaos
January 2025
Jožef Stefan Institute, Jamova cesta 39, SI-1000 Ljubljana, Slovenia.
Detecting directional couplings from time series is crucial in understanding complex dynamical systems. Various approaches based on reconstructed state-spaces have been developed for this purpose, including a cross-distance vector measure, which we introduced in our recent work. Here, we devise two new cross-vector measures that utilize ranks and time series estimates instead of distances.
View Article and Find Full Text PDFNationwide population-based infection- and vaccine-induced SARS-CoV-2 antibody seroprevalence in Germany in autumn/winter 2021/2022.
Euro Surveill
January 2025
RKI-SOEP-2 Study Group is acknowledged at the end of the article.
BackgroundThe first Corona Monitoring Nationwide (RKI-SOEP) study (October 2020-February 2021) found a low pre-vaccine SARS-CoV-2 antibody seroprevalence (2.1%) in the German adult population (≥ 18 years).AimThe objective of this second RKI-SOEP (RKI-SOEP-2) study in November 2021-March 2022 was to estimate the prevalence of SARS-CoV-2-specific anti-spike and/or anti-nucleocapsid (anti-N) IgG antibodies (combined seroprevalence), past infection based on infection-induced seroprevalence (anti-N), and basic immunisation (at least two antigen contacts through vaccination or infection) in individuals aged ≥ 14 years.
View Article and Find Full Text PDFSmoothed Particle Hydrodynamics for free-surface and multiphase flows: a review.
Rep Prog Phys
January 2025
Istituto di Ingegneria del Mare Consiglio Nazionale delle Ricerche, Via di Vallerano 139, Roma, Lazio, 00128, ITALY.
The Smoothed Particle Hydrodynamics (SPH) method is expanding and applied to more and more fields, particularly in engineering. The majority of current SPH developments deal with free-surface and multiphase flows, especially for situations where geometrically complex interface configurations are involved. The present review article covers the last 25 years of development of the method to simulate such flows, discussing the related specific features of the method.
View Article and Find Full Text PDFDynamic factor analysis with multivariate time series of multiple individuals: An error-corrected estimation method.
Psychol Methods
January 2025
Department of Human Development, Cornell University.
Intensive longitudinal data, increasingly common in social and behavioral sciences, often consist of multivariate time series from multiple individuals. Dynamic factor analysis, combining factor analysis and time series analysis, has been used to uncover individual-specific processes from single-individual time series. However, integrating these processes across individuals is challenging due to estimation errors in individual-specific parameter estimates.
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