The demand for high-resolution and large-area imaging systems for non-destructive wafer inspection has grown owing to the increasing complexity and extremely fine nature of semiconductor processes. Several studies have focused on developing high-resolution imaging systems; however, they were limited by the tradeoff between image resolution and field of view. Hence, computational imaging has arisen as an alternative method to conventional optical imaging, aimed at enhancing the aforementioned parameters. This study proposes a method for improving the resolution and field of view of an image in a lens-less reflection-type system. Our method was verified by computationally restoring the final image from diffraction images measured at various illumination positions using a visible light source. We introduced speckle illumination to expand the numerical aperture of the entire system, simultaneously improving image resolution and field of view. The image reconstruction process was accelerated by employing a convolutional neural network. Using the reconstructed phase images, we implemented high-resolution topography and demonstrated its applicability in wafer surface inspection. Furthermore, we demonstrated an ideal diffraction-limited spatial resolution of 1.7 μm over a field of view of 1.8 × 1.8 mm for the topographic imaging of targets with various surface roughness. The proposed approach is suitable for applications that simultaneously require high throughput and resolution, such as wafer-wide integrated metrology, owing to its compact design, cost-effectiveness, and mechanical robustness.
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http://dx.doi.org/10.1038/s41598-024-59496-4 | DOI Listing |
J Orthop Surg Res
January 2025
Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, P. R. China.
Objective: To investigate the application value of arthroscopic channel modification in meniscal injury repair.
Methods: We retrospectively analyzed the data of 100 patients with meniscus injuries treated with knee arthroscopy from December 2022 to December 2023 and divided them into a control group and a modified group according to the application of "arthroscopic access modification technology". We compared the operation time, postoperative hospitalization time, VAS score, Lysholm knee function score, postoperative complications, and postoperative images of the patients in these two groups.
Nat Commun
January 2025
State Key Laboratory of Terahertz and Millimeter Waves, City University of Hong Kong, Hong Kong, 999077, China.
Terahertz (THz) lens constitutes a vital component in the THz system. Metasurfaces-based THz metalenses and classical bulky lenses are severely constrained by chromatic/ spherical aberration and the diffraction limit. Consequently, achromatic super-resolution THz lenses are urgently needed.
View Article and Find Full Text PDFBiosens Bioelectron
December 2024
Computational Modeling and Nanoscale Processing Unit, Department of Food Process Engineering, National Institute of Food Technology Entrepreneurship and Management, Thanjavur (NIFTEM-T), Ministry of Food Processing Industries, Government of India, Thanjavur, 613005, Tamil Nadu, India. Electronic address:
A recently minted field of 3D-printed edible electronics (EEs) represents a cutting-edge convergence of edible electronic devices and 3D printing technology. This review presents a comprehensive view of this emerging discipline, which has gathered significant scientific attention for its potential to create a safe, environmentally friendly, economical, and naturally degraded inside the human body. EEs have the potential to be used as medical and health devices to monitor physiological conditions and possibly treat diseases.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Virginia, Charlottesville, VA, USA.
Background: The microvasculature of the central nervous system (CNS), which delivers oxygen and nutrients and forms a critical barrier protecting the CNS, is deleteriously affected by both Alzheimer's Disease (AD) and Type 2 Diabetes (T2D). Previous studies have shown pericyte dropout and vessel constriction in brain capillaries in AD, while other studies have shown pericyte bridging and dropout in retinal capillaries in T2D. T2D patients have increased risk of AD, suggesting potentially related microvascular pathological mechanisms.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY, USA; Columbia University Irving Medical Center, New York, NY, USA.
The view of microglial role in the pathogenesis of Alzheimer's disease (AD) has been shaped by two major breakthroughs in the past decade: the discovery that many of the AD susceptibility genes are preferentially expressed in microglia, and the finding that microglia exist in a variety of previously not described functional phenotypes in the aged human central nervous system. As much as these discoveries brought paradigm shifts to the field, they also revealed major gaps in our understanding of the functional consequences of both the expression of AD susceptibility genes and microglia phenotypic heterogeneity. While there is progress being made in understanding the role of individual AD susceptibility genes in microglia function and what role the different microglia phenotypes might play in disease pathogenesis in AD, the connection between these two determining factors has not been established yet.
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