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Current challenges in the discovery of treatments against Mayaro fever. | LitMetric

Current challenges in the discovery of treatments against Mayaro fever.

Expert Opin Ther Targets

Department of Pathology and Center for Research in Vector-Borne and Zoonotic Diseases, University of Texas Medical Branch, Galveston, TX, USA.

Published: May 2024

AI Article Synopsis

  • Mayaro fever is an emerging viral disease characterized by fever and joint pain, with no specific treatment available, resulting in socioeconomic impacts and strain on health systems.
  • The review explores potential treatments for Mayaro virus infection, evaluating various antiviral compounds and the technologies used for testing their effectiveness.
  • Despite promising candidate treatments, many face challenges in advancing to clinical trials due to insufficient experimental models and limited understanding of Mayaro virus biology, although targeting inflammatory responses may be a beneficial therapeutic approach.

Article Abstract

Introduction: Mayaro fever is an emerging viral disease that manifests as an acute febrile illness. The disease is self-limiting, however joint pain can persist for months leading to chronic arthralgia. There is no specific treatment available, which ultimately leads to socioeconomic losses in populations at risk as well as strains to the public health systems.

Areas Covered: We reviewed the candidate treatments proposed for Mayaro virus (MAYV) infection and disease, including antiviral compounds targeting viral or host mechanisms, and pathways involved in disease development and pathogenicity. We assessed compound screening technologies and experimental infection models used in these studies and indicated the advantages and limitations of available technologies and intended therapeutic strategies.

Expert Opinion: Although several compounds have been suggested as candidate treatments against MAYV infection, notably those with antiviral activity, most compounds were assessed only . Compounds rarely progress to or preclinical studies, and such difficulty may be associated with limited experimental models. MAYV biology is largely inferred from related alphaviruses and reflected by few studies focusing on target proteins or mechanisms of action for MAYV. Therapeutic strategies targeting pathogenic inflammatory responses have shown potential against MAYV-induced disease , which might reduce long-term sequelae.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11189740PMC
http://dx.doi.org/10.1080/14728222.2024.2351504DOI Listing

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