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Value of CT diagnostic techniques based on imaging post-processing systems in the early diagnosis and treatment of lung cancer.
Am J Transl Res
December 2024
Respiratory and Critical Care Medicine, Nan'an City Hospital Quanzhou 362399, Fujian, China.
Objective: To evaluate the application value of CT diagnostic technology based on the Shukun Imaging Post-Processing System for early screening and diagnosis of lung cancer.
Methods: A total of 35 patients diagnosed with lung cancer postoperatively and 53 patients with benign nodules were included in this retrospective study, all of whom were treated in the Department of Thoracic and Cardiovascular Surgery of the Second Affiliated Hospital of Fujian Medical University from January 2020 to December 2023. All patients underwent chest spiral CT examinations.
High-resolution X-ray phase-contrast tomography of human placenta with different wavefront markers.
Sci Rep
January 2025
Department of Physics, University of Trieste, 34127, Trieste, Italy.
Phase-contrast micro-tomography ([Formula: see text]CT) with synchrotron radiation can aid in the differentiation of subtle density variations in weakly absorbing soft tissue specimens. Modulation-based imaging (MBI) extracts phase information from the distortion of reference patterns, generated by periodic or randomly structured wavefront markers (e.g.
View Article and Find Full Text PDFGIS-based assessment of photovoltaic solar potential on building rooftops in equatorial urban areas.
Heliyon
January 2025
Universidad de Cuenca, Laboratorio de Ecología Acuática (LEA), Balzay Campus, Cuenca, 010107, Ecuador.
Installing photovoltaic systems (PVs) on building rooftops is a viable and sustainable alternative to meet the growing demand for electricity in cities. This work develops a methodology that uses LiDAR (laser imaging detection and ranging) technology and roof footprints to obtain a three-dimensional representation of the rooftops in the urban centre of Santa Isabel (Azuay, Ecuador). This allowed the determination of characteristics such as area, slope, orientation, and received solar radiation, making it possible to calculate the rooftop's theoretical, technical, and economic photovoltaic potential.
View Article and Find Full Text PDFExploring oncology treatment strategies with tyrosine kinase inhibitors through advanced 3D models (Review).
Med Int (Lond)
December 2024
Department of Clinical and Experimental Medicine, Endocrine Unit 2, University of Pisa, I-56122 Pisa, Italy.
The limitations of two-dimensional (2D) models in cancer research have hindered progress in fully understanding the complexities of drug resistance and therapeutic failures. However, three-dimensional (3D) models provide a more accurate representation of environments, capturing critical cellular interactions and dynamics that are essential in evaluating the efficacy and toxicity of tyrosine kinase inhibitors (TKIs). These advanced models enable researchers to explore drug resistance mechanisms with greater precision, optimizing treatment strategies and improving the predictive accuracy of clinical outcomes.
View Article and Find Full Text PDFDoxorubicin and topotecan resistance in ovarian cancer: Gene expression and microenvironment analysis in 2D and 3D models.
Biomed Pharmacother
January 2025
Institute of Health Sciences, Collegium Medicum, University of Zielona Góra, Zyty 28 St., Zielona Góra 65-046, Poland. Electronic address:
This study explores the mechanisms underlying chemotherapy resistance in ovarian cancer (OC) using doxorubicin (DOX) and topotecan (TOP)-resistant cell lines derived from the drug-sensitive A2780 ovarian cancer cell line. Both two-dimensional (2D) monolayer cell cultures and three-dimensional (3D) spheroid models were employed to examine the differential drug responses in these environments. The results revealed that 3D spheroids demonstrated significantly higher resistance to DOX and TOP than 2D cultures, suggesting a closer mimicry of in vivo tumour conditions.
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