AI Article Synopsis
- The study investigates focused ultrasound (FUS) as a method to non-invasively deliver gold nanoparticles (AuNPs) across the blood-retinal barrier (BRB) for treating retinal disorders.
- Researchers optimized FUS parameters to ensure effective delivery while preventing retinal damage, demonstrating the successful transportation of AuNPs and other substances to the retina in a rodent model.
- Findings suggest that smaller AuNPs are more effective at penetrating the retinal layers, paving the way for new non-invasive therapies in the treatment of retinal diseases.
Article Abstract
Purpose: The blood-retinal barrier (BRB) restricts the delivery of intravenous therapeutics to the retina, necessitating innovative approaches for treating retinal disorders. This study sought to explore the potential of focused ultrasound (FUS) to non-invasively deliver intravenously administered gold nanoparticles (AuNPs) across the BRB. FUS-BRB modulation can offer a novel method for targeted retinal therapy.
Methods: AuNPs of different sizes and shapes were characterized, and FUS parameters were optimized to permeate the BRB without causing retinal damage in a rodent model. The delivery of 70-kDa dextran and AuNPs to the retinal ganglion cell (RGC) layer was visualized using confocal and two-photon microscopy, respectively. Histological and statistical analyses were conducted to assess the effectiveness and safety of the procedure.
Results: FUS-BRB modulation resulted in the delivery of dextran and AuNPs to the RGC and inner nuclear layer. Smaller AuNPs reached the retinal layers to a greater extent than larger ones. The delivery of dextran and AuNPs across the BRB with FUS was achieved without significant retinal damage.
Conclusions: This investigation provides the first evidence, to our knowledge, of FUS-mediated AuNP delivery across the BRB, establishing a foundation for a targeted and non-invasive approach to retinal treatment. The results contribute to developing promising non-invasive therapeutic strategies in ophthalmology to treat retinal diseases.
Translational Relevance: Modifying the BRB with ultrasound offers a targeted and non-invasive delivery strategy of intravenous therapeutics to the retina.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086706 | PMC |
| http://dx.doi.org/10.1167/tvst.13.5.5 | DOI Listing |
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Article Synopsis
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