Aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (ARNT) mediate the responses of adaptive metabolism to various xenobiotics. Here, we found that and are highly expressed in the midgut of larvae. The expression of and was significantly increased after exposure to imidacloprid and phoxim. The knockdown of and significantly decreased the expression of and as well as P450 enzyme activity and caused a significant increase in the sensitivity of larvae to imidacloprid and phoxim. Exposure to β-naphthoflavone (BNF) significantly increased the expression of , , and as well as P450 activity and decreased larval sensitivity to imidacloprid and phoxim. Furthermore, and were significantly induced by imidacloprid and phoxim, and the silencing of these two genes significantly reduced larval tolerance to imidacloprid and phoxim. Taken together, the BoAhRBoARNT pathway plays key roles in larval tolerance to imidacloprid and phoxim by regulating the expression of and .
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