AI Article Synopsis
- A 60-year-old woman was diagnosed with advanced lung cancer (stage IVB) with a specific genetic mutation and began treatment with osimertinib.
- After one month of osimertinib treatment, she developed cough and lung issues due to drug-induced pneumonitis, which resolved after stopping the medication.
- Twenty months later, she had brain and leptomeningeal metastases; osimertinib was restarted successfully without causing pneumonitis for another eight months.
Article Abstract
A 60-year-old woman was diagnosed with cT4N3M1c stage IVB lung adenocarcinoma with epidermal growth factor receptor mutation of exon19 deletion. After one month of treatment with osimertinib, a cough and diffuse ground glass opacities were observed in the bilateral lung field. Based on the clinical course and the exclusion of other etiologies, osimertinib-induced pneumonitis was diagnosed. The shadows resolved after osimertinib was discontinued. However, brain metastasis and leptomeningeal metastasis developed 20 months later; therefore, osimertinib was re-administered without concomitant corticosteroids. The pulmonary lesion and leptomeningeal metastasis were successfully treated without recurrence of drug-induced pneumonitis for eight months.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11070756 | PMC |
| http://dx.doi.org/10.1016/j.rmcr.2024.102029 | DOI Listing |
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