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| http://dx.doi.org/10.1093/function/zqae018 | DOI Listing |
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MYT1L is a neuronal transcription factor highly expressed in the developing and adult brain. While pathogenic mutation causes neurodevelopmental disorders, these have not been characterized in human models of neurodevelopment. Here, we defined the consequences of pathogenic mutation in human pluripotent stem cell-derived cortical interneurons.
View Article and Find Full Text PDF[Reversibility of a critical intraventricular conduction delay under flecainide and lacosamide by sodium bicarbonate].
Inn Med (Heidelb)
December 2024
Klinik für Innere Medizin, Kardiologie und Angiologie, Schön Klinik Eilbek, Dehnhaide 120, 22081, Hamburg, Deutschland.
The case of a 72-year-old female patient with arrhythmogenic syncope associated with a combination therapy of flecainide and lacosamide is presented. The authors believe in an additive effect of both drugs on myocardial voltage-gated sodium channels with extraordinary QRS widening, exit block with temporary pacing and complete reversibility through infusion of sodium bicarbonate as bail-out therapy.
View Article and Find Full Text PDFHyperglycemia-independent neonatal streptozotocin-induced retinopathy (NSIR) in rats.
Front Pharmacol
July 2024
Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
Chemicals, such as MNU (N-methyl-N-nitrosourea) and NaIO3 (sodium iodate), are widely used to induce retinal degeneration in rodents. Streptozotocin (STZ) is an analog of N-acetyl glucosamine in which an MNU moiety is linked to a hexose and has a special toxic effect on insulin-producing pancreatic β-cells. It is commonly used to induce hyperglycemia to model diabetes.
View Article and Find Full Text PDFOccurrence and abundance of microplastics in surface water of Songkhla Lagoon.
PeerJ
July 2024
Faculty of Environmental Management, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Background: Microplastic (MP) pollution is now a global critical issue and has been the subject of considerable worry for multiple various types of habitats, notably in lagoons which are coastal areas connected to the ocean. MPs are of concern, particularly because floating MP in surface water can be ingested by a number of marine organisms. There are several lagoons along Southeast Asia's coastline, but Songkhla Lagoon is Thailand's only exit with a rich biodiversity.
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