Objectives: To evaluate an optimized deep leaning-based image post-processing technique in lumbar spine MRI at 0.55 T in terms of image quality and image acquisition time.
Materials And Methods: Lumbar spine imaging was conducted on 18 patients using a 0.55 T MRI scanner, employing conventional (CDLR) and advanced (ADLR) deep learning-based post-processing techniques. Two musculoskeletal radiologists visually evaluated the images using a 5-point Likert scale to assess image quality and resolution. Quantitative assessment in terms of signal intensities (SI) and contrast ratios was performed by region of interest measurements in different body-tissues (vertebral bone, intervertebral disc, spinal cord, cerebrospinal fluid and autochthonous back muscles) to investigate differences between CDLR and ADLR sequences.
Results: The images processed with the advanced technique (ADLR) were rated superior to the conventional technique (CDLR) in terms of signal/contrast, resolution, and assessability of the spinal canal and neural foramen. The interrater agreement was moderate for signal/contrast (ICC = 0.68) and good for resolution (ICC = 0.77), but moderate for spinal canal and neuroforaminal assessability (ICC = 0.55). Quantitative assessment showed a higher contrast ratio for fluid-sensitive sequences in the ADLR images. The use of ADLR reduced image acquisition time by 44.4%, from 14:22 min to 07:59 min.
Conclusions: Advanced deep learning-based image reconstruction algorithms improve the visually perceived image quality in lumbar spine imaging at 0.55 T while simultaneously allowing to substantially decrease image acquisition times.
Clinical Relevance: Advanced deep learning-based image post-processing techniques (ADLR) in lumbar spine MRI at 0.55 T significantly improves image quality while reducing image acquisition time.
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http://dx.doi.org/10.1016/j.ejro.2024.100567 | DOI Listing |
Cancer Cell Int
January 2025
Department of Immuno-Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, 510080, China.
Background: Patients with lung adenocarcinoma (LUAD) receiving drug treatment often have an unpredictive response and there is a lack of effective methods to predict treatment outcome for patients. Dendritic cells (DCs) play a significant role in the tumor microenvironment and the DCs-related gene signature may be used to predict treatment outcome. Here, we screened for DC-related genes to construct a prognostic signature to predict prognosis and response to immunotherapy in LUAD patients.
View Article and Find Full Text PDFBMJ Open Ophthalmol
January 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China
Objective: We compared the protein structure and pathogenicity of clinically relevant variants of the gene with AlphaFold2 (AF2), Alpha Missense (AM), and ThermoMPNN for the first time.
Methods And Analysis: The sequences of clinically relevant Cog4 missense variants (one novel identified p.Y714F and three pre-existing p.
Comput Biol Med
January 2025
Department of Orthopedics, Affiliated Huzhou Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Huzhou, China; Department of Sports Medicine & Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Institute of sports medicine, Zhejiang University, Hangzhou, China; Orthopedics Research Institute of Zhejiang University, Hangzhou, China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, China; Clinical Research Center of Motor System Disease of Zhejiang Province, Hangzhou, China. Electronic address:
Background: Effective drugs for tendinopathy are lacking, resulting in significant morbidity and re-tearing rate after operation. Applying systems biology to identify new applications for current pharmaceuticals can decrease the duration, expenses, and likelihood of failure associated with the development of new drugs.
Methods: We identify tendinopathy signature genes employing a transcriptomics database encompassing 154 clinical tendon samples.
Comput Biol Med
January 2025
Department of Artificial Intelligence, Faculty of Artificial Intelligence, Egyptian Russian University, 11829, Badr City, Egypt. Electronic address:
Weakly-supervised learning (WSL) methods have gained significant attention in medical image segmentation, but they often face challenges in accurately delineating boundaries due to overfitting to weak annotations such as bounding boxes. This issue is particularly pronounced in thyroid ultrasound images, where low contrast and noisy backgrounds hinder precise segmentation. In this paper, we propose a novel weakly-supervised segmentation framework that addresses these challenges.
View Article and Find Full Text PDFClin Neuroradiol
January 2025
Department of Diagnostic and Interventional Radiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.
Introduction: Ventriculoperitoneal shunts (VPS) are an essential part of the treatment of hydrocephalus, with numerous valve models available with different ways of indicating pressure levels. The model types often need to be identified on X‑rays to assess pressure levels using a matching template. Artificial intelligence (AI), in particular deep learning, is ideally suited to automate repetitive tasks such as identifying different VPS valve models.
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