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Regulatory gaps in India's medical device framework: The case of Johnson and Johnson's faulty hip implants.
World J Orthop
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Law, Gujarat National Law University, Ahmedabad 382426, Gujarat, India.
The Johnson and Johnson faulty hip implant case represents one of the most significant crises in medical device history, impacting nearly 93000 patients worldwide. In response to alarming failure rates and a global recall in August 2010, countries such as Australia, the United States, and the United Kingdom quickly implemented revision surgeries and reimbursement programs to protect patient safety. In stark contrast, India's response was alarmingly delayed; defective implants continued to be sold even after the global recall.
View Article and Find Full Text PDFNeurochallenges in smart cities: state-of-the-art, perspectives, and research directions.
Front Neurosci
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The Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Türkiye.
Smart city development is a complex, transdisciplinary challenge that requires adaptive resource use and context-aware decision-making practices to enhance human functionality and capabilities while respecting societal and environmental rights, and ethics. There is an urgent need for action in cities, particularly to (i) enhance the health and wellbeing of urban residents while ensuring inclusivity in urban development (e.g.
View Article and Find Full Text PDFNew series of 3-pyridyl-1,3-thiazoles: In vitro and in vivo anti-Trypanosomatidae profile, in vitro and in silico mechanism of action approach.
Eur J Med Chem
December 2024
Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco, 50740-535, Recife, PE, Brazil. Electronic address:
Trypanosomatidae diseases, such as Chagas disease and leishmaniasis, are caused by protozoan parasites of the Trypanosomatidae family, namely Trypanosoma cruzi and Leishmania species, respectively. There is an urgent need for new therapies. Both pyridine and thiazole rings are recognized as important scaffolds in medicinal chemistry.
View Article and Find Full Text PDFZingerone effect against Candida albicans growth and biofilm production.
J Mycol Med
December 2024
Department of Stem Cell and Regenerative Medicine and Medical Biotechnology, Centre for Interdisciplinary Research, DY Patil Education Society (Deemed to be University), Kolhapur, Maharashtra, 416003, India. Electronic address:
Background: The increasing resistance of Candida albicans biofilms underscores the urgent need for effective antifungals. This study evaluated the efficacy of zingerone and elucidated its mode of action against C. albicans ATCC 90028 and clinical isolate C1.
View Article and Find Full Text PDFAntifungal peptides from living organisms.
Front Microbiol
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Key Laboratory of Biological Resources and Ecology of Pamirs Plateau in Xinjiang Uygur Autonomous Region, College of Life and Geographic Sciences, Kashi University, Kashi, China.
In the post-COVID-19 era, people are increasingly concerned about microbial infections, including fungal infections that have risen in recent years. However, the currently available antifungal agents are rather limited. Worse still, the widespread use of the antifungal agents has caused the emergence of antifungal resistance in , , and species.
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