AI Article Synopsis
- Prion diseases are deadly neurodegenerative disorders that can be transmitted, and hydroxypropyl methylcellulose compounds (HPMCs) show promise as anti-prion agents.
- Stearoxy-modified HPMCs enhanced anti-prion effects in infected cells and extended the incubation time in certain mouse models.
- However, in mouse models that already responded well to HPMCs, the stearoxy modification didn't provide additional benefits, suggesting a new approach for less responsive cases.
Article Abstract
Prion diseases are fatal transmissible neurodegenerative disorders. Among known anti-prions, hydroxypropyl methylcellulose compounds (HPMCs) are unique in their chemical structure and action. They have several excellent anti-prion properties but the effectiveness depends on the prion-infected mouse model. In the present study, we investigated the effects of stearoxy-modified HPMCs on prion-infected cells and mice. Stearoxy modification improved the anti-prion efficacy of HPMCs in prion-infected cells and significantly prolonged the incubation period in a lower HPMC-responding mouse model. However, stearoxy modification showed no improvement over nonmodified HPMCs in an HPMC-responding mouse model. These results offer a new line of inquiry for use with prion-infected mice that do not respond well to HPMCs.
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| http://dx.doi.org/10.1016/j.carbpol.2024.122163 | DOI Listing |
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