AI Article Synopsis
- - Patients with Hashimoto's thyroiditis show higher numbers of Th17 cells and elevated interleukin 17 (IL-17) levels in their serum and thyroid tissue.
- - There is an imbalance between Th17 cells and regulatory T cells (Tregs), resulting in a lower Tregs ratio that decreases the thyroid gland's ability to suppress immune responses.
- - Th17 cells contribute to the progression of Hashimoto's thyroiditis by promoting inflammation and fibrosis in the thyroid tissue through IL-17 production.
Article Abstract
Patients with Hashimoto's thyroiditis had increased numbers of Th17 cells in serum and thyroid tissue, significantly elevated levels of interleukin 17 (IL-17), and an imbalance in the ratio of Th17 cells to regulatory T cells (Tregs). The reduced Tregs' ratio leads to a reduction in immunosuppressive function within the thyroid gland, while Th17 cells are involved in the development of HT by regulating the expression of pro-inflammatory cytokines in the thyroid gland and mediating thyroid tissue fibrosis through the secretion of IL-17.
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