A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: Attempt to read property "Count" on bool

Filename: helpers/my_audit_helper.php

Line Number: 3100

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Predictive Factors of Cloxacillin Susceptibility in Primary Bacterial Spinal Infection. | LitMetric

Predictive Factors of Cloxacillin Susceptibility in Primary Bacterial Spinal Infection.

Global Spine J

Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Hong Kong, China.

Published: May 2024

AI Article Synopsis

  • The study aimed to determine factors that predict cloxacillin susceptibility in spinal infections, analyzing patient data from 1997 to 2021.
  • It found that over 40% of bacterial isolates were resistant to cloxacillin, with certain factors like low globulin levels and recent hospitalizations indicating cloxacillin resistance.
  • Additionally, higher red cell distribution width and Charlson comorbidity index scores were linked to a greater risk of mortality within one year, suggesting the need for alternative antibiotic therapies and careful patient management.

Article Abstract

Study Design: Prognostic study.

Objectives: The objective of this study is to identify predictive factors for cloxacillin susceptibility in spinal infections.

Methods: A retrospective analysis was conducted using data from January 1, 1997, to December 31, 2021. The study included patients presenting with back pain and either a positive bacterial culture from the spine or radiological evidence of spinal infection (spondylodiscitis and/or epidural abscess) along with positive bacterial blood culture.

Results: Among 171 patients (127 males, 44 females), 53.2% had isolates, with 40.4% showing cloxacillin resistance. Lower globulin levels (<33.5 g/L), recent hospitalization within 90 days, and residence in an old age home predicted gram-positive bacteria with cloxacillin resistance and gram-negative bacteria as causative organisms (<.05). The 30-day and 1-year all-cause mortality rates were 0% and 8.2%, respectively. Higher red cell distribution width (RDW >16.1%) and Charlson comorbidity index (CCI) scores predicted 1-year all-cause mortality (<.05). Intensive care unit admission was required for 9.9% of patients.

Conclusions: This study identified predictive factors for spinal infection by gram-positive bacteria with cloxacillin resistance and gram-negative bacteria. Patients with lower globulin levels (<33.5 g/L), recent hospitalization within 90 days, or residency in an old age home upon admission should avoid standalone cloxacillin therapy and consider antibiotics with gram-negative coverage. Higher RDW (>16.1%) and CCI scores were associated with increased 1-year all-cause mortality. These findings contribute to treatment decision-making and improving patient outcomes in spinal infections.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571538PMC
http://dx.doi.org/10.1177/21925682241251814DOI Listing

Publication Analysis

Top Keywords

predictive factors
8
factors cloxacillin
8
cloxacillin susceptibility
8
spinal infection
8
positive bacterial
8
susceptibility primary
4
primary bacterial
4
bacterial spinal
4
infection study
4
study design
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: