AI Article Synopsis
- - This study evaluates the effectiveness of various diagnostic methods for brain tuberculoma (BT) by analyzing tissue specimens from 16 patients, both HIV-positive and negative.
- - Key diagnostic techniques used included acid-fast bacilli (AFB) stain, PCR, Gene Xpert, and histopathology, revealing that AFB stain and PCR were positive for most patients, and histopathology confirmed BT in over half.
- - After treatment with antituberculosis medication, 75% of the patients showed significant clinical improvement, suggesting that combining diagnostic methods enhances the accuracy of BT diagnosis.
Article Abstract
The diagnosis of brain tuberculoma (BT) is sometimes challenging. Herein, we presented a case series to evaluate the combined-diagnostic methods, including acid-fast bacilli (AFB) stain, polymerase chain reaction (PCR), Gene Xpert, and histopathology, of tuberculoma tissue specimens (TTSs). A total of 16 patients (11 human immunodeficiency virus [HIV]-positive, 5 HIV-negative) with BT confirmed by combined-diagnostic methods of TTS were included in this study. Clinical data, including clinical symptoms, laboratory tests, neuroimaging features, histopathology, treatment, and prognosis, were assessed in all patients. There were 10 male and 6 female patients (range, 18-73 years). Acid-fast bacilli stain and PCR of TTSs were positive in 11 and 10 patients, respectively. The sensitivity of Gene Xpert of TTSs was (80.0%; 8/10). Nine (56.3%; 9/16) patients were diagnosed with BT by histopathology. After receiving antituberculosis treatment, 12 (75.0%; 12/16) patients improved clinically to a considerable extent. The combined-diagnostic methods of TTS may improve the diagnostic efficiency of BT.
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| http://dx.doi.org/10.1089/sur.2023.358 | DOI Listing |
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