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Benzoyl Valine Quasiracemates: Pairing CF Quasienantiomers with H to -Butyl. | LitMetric

Benzoyl Valine Quasiracemates: Pairing CF Quasienantiomers with H to -Butyl.

Cryst Growth Des

Department of Chemistry, Whitworth University, 300 West Hawthorne Road, Spokane, Washington 99251, United States.

Published: May 2024

AI Article Synopsis

Article Abstract

Understanding the interplay of structural features responsible for molecular assembly is essential for molecular crystal engineering. When assembling molecules with encoded motifs, supramolecular strategies almost always include robust directional nonbonded contacts. Quasiracemic materials, considered near racemates since cocrystallization occurs with chemically unique components, lack a molecular framework or functional group restrictions, highlighting the importance of molecular shape to molecular assembly. Recently, our group reported quasiracemates derived from benzoyl leucine/phenylalanine derivatives with two points of chemical difference. In this study, we modified the chemical framework with valine and increased the scope of the work by imposing a larger variance in the side chain substituents. Pairing a CF component with quasienantiomers that differ iteratively from hydrogen to -butyl offers an important view into the supramolecular landscape of these materials. Single-crystal X-ray crystallography and lattice energy assessments, coupled with conformational and crystal structure similarity searches, show an elevated degree of isomorphism for many of the targeted 17 racemates and quasiracemates. These benzoyl amino acid molecular architectures create extended hydrogen-bond patterns in the crystal that provide enhanced opportunities to study the shape space and molecular recognition profiles for a diverse family of quasienantiomeric components.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11066836PMC
http://dx.doi.org/10.1021/acs.cgd.4c00307DOI Listing

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