AI Article Synopsis
- Preventive cancer vaccines are effective against cancers caused by viral infections, but progress in therapeutic vaccines designed to eliminate existing cancer cells is limited.
- *The integration of better adjuvants—substances that enhance the body's immune response—is crucial for improving therapeutic cancer vaccines, as current conventional adjuvants do not meet clinical trial standards.
- *The review focuses on advancements in therapeutic cancer vaccines, exploring innovative vaccination strategies and novel adjuvants that can work alongside other immunotherapies to boost therapeutic outcomes.
Article Abstract
Preventive cancer vaccines are highly effective in preventing viral infection-induced cancer, but advances in therapeutic cancer vaccines with a focus on eliminating cancer cells through immunotherapy are limited. To develop therapeutic cancer vaccines, the integration of optimal adjuvants is a potential strategy to enhance or complement existing therapeutic approaches. However, conventional adjuvants do not satisfy the criteria of clinical trials for therapeutic cancer vaccines. To improve the effects of adjuvants in therapeutic cancer vaccines, effective vaccination strategies must be formulated and novel adjuvants must be identified. This review offers an overview of the current advancements in therapeutic cancer vaccines and highlights in situ vaccination approaches that can be synergistically combined with other immunotherapies by harnessing the adjuvant effects. Additionally, the refinement of adjuvant systems using cutting-edge technologies and the elucidation of molecular mechanisms underlying immunogenic cell death to facilitate the development of innovative adjuvants have been discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11066472 | PMC |
| http://dx.doi.org/10.1016/j.csbj.2024.04.054 | DOI Listing |
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