AI Article Synopsis
- The article examines various oral cancer precursor syndromes, particularly focusing on hereditary disorders like dyskeratosis congenita and Fanconi anemia that elevate cancer risk.
- It highlights oral potentially malignant disorders, especially leukoplakia, emphasizing the roles of genetics and immune factors in their development.
- Lastly, the discussion includes management strategies for leukoplakia, such as surgery and immune therapies, while addressing the difficulties in creating effective preventive methods.
Article Abstract
This article explores the multifaceted landscape of oral cancer precursor syndromes. Hereditary disorders like dyskeratosis congenita and Fanconi anemia increase the risk of malignancy. Oral potentially malignant disorders, notably leukoplakia, are discussed as precursors influenced by genetic and immunologic facets. Molecular insights delve into genetic mutations, allelic imbalances, and immune modulation as key players in precancerous progression, suggesting potential therapeutic targets. The article navigates the controversial terrain of management strategies of leukoplakia, encompassing surgical resection, chemoprevention, and immune modulation, while emphasizing the ongoing challenges in developing effective, evidence-based preventive approaches.
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| http://dx.doi.org/10.1016/j.hoc.2024.04.001 | DOI Listing |
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