First Successful Pregnancy After Lung Transplantation in Poland-Case Report.

Transplant Proc

Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland.

Published: May 2024

AI Article Synopsis

  • - Lung transplantation can be a viable treatment for cystic fibrosis (CF) patients with severe lung issues, and while pregnancy is possible for these patients, it involves significant challenges and requires a coordinated healthcare approach.
  • - A case study details a 22-year-old woman who became pregnant 2.5 years post-lung transplant, where she was closely monitored and had her medications adjusted to avoid complications.
  • - Successful delivery of a healthy baby was achieved through a planned caesarean section, demonstrating that with proper care and patient cooperation, pregnancy after lung transplantation can result in positive outcomes.

Article Abstract

Introduction: Lung transplantation is well-established treatment for patients with advanced lung dysfunction in cystic fibrosis (CF). Pregnancy in CF lung transplant recipients is feasible, although it still remains challenging for even professionals and demands a multidisciplinary approach.

Case Report: We report the case of pregnancy in a 22-year-old woman after lung transplantation (LTx) due to end-stage respiratory failure in the course of CF. The interval from transplant to conception was 2.5 years. In 2019, orthotopic LTx was performed and a 3-drug immunosuppressive scheme was used-tacrolimus, mycophenolate mofetil, and prednisolone. There were no complications in the postoperative course. In April 2022, the patient was confirmed pregnant. All fetotoxic or teratogenic drugs were discontinued. Throughout the whole pregnancy, the patient was regularly monitored in the transplant and obstetrics centers. Due to the vaginal bleeding and irregular contractions at the 33 weeks of pregnancy, the course of steroids was administered. At 38 weeks and 5 days of gestation, she presented premature rupture of membranes. The caesarean section was performed because of breech presentation of the fetus. A live, term daughter was born and according to the screening test she does not have CF. Currently, 12 months after the delivery, the mother's lung function is good.

Conclusions: Getting pregnant and having a safe pregnancy after LTx is possible, but it requires a specialized and individual approach. The patient should be well informed about possible complications and risks including graft failure. The patient's attitude and her cooperation with doctors play a major role.

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Source
http://dx.doi.org/10.1016/j.transproceed.2024.03.016DOI Listing

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