Continuous peripheral nerve block catheters are simple in concept: percutaneously inserting a catheter adjacent to a peripheral nerve. This procedure is followed by local anesthetic infusion via the catheter that can be titrated to effect for extended anesthesia or analgesia in the perioperative period. The reported benefits of peripheral nerve catheters used in the surgical population include improved pain scores, decreased narcotic use, decreased nausea/vomiting, decreased pruritus, decreased sedation, improved sleep, and improved patient satisfaction.
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A single blinded randomized controlled trial assessing the effect of photobiomodulation therapy on neuron specific biomarkers in type II diabetes mellitus patients with peripheral neuropathy.
Diabetes Res Clin Pract
March 2025
Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India. Electronic address:
Background: Diabetic peripheral neuropathy is one of the most devastating complications of long-term diabetes mellitus, associated with functional limitations and poor quality of life.
Materials And Methods: Two hundred subjects were randomized into intervention and control group, with one hundred in each arm. The intervention arm received photobiomodulation therapy for ten days, with Low -Level Helium-Neon Laser at a wavelength of 632.
Guanine and isoguanine promote axon regeneration of dorsal root ganglion neurons and survival of retinal ganglion cells after injury.
Exp Neurol
March 2025
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Medical School of Nantong University, Nantong University, Nantong 226001, China. Electronic address:
Neurological injuries usually lead to motor, sensory, or cognitive impairment, which urgently need the development of effective therapeutic strategies. An increasing number of studies have indicated that metabolites can serve as therapeutic drugs for treating diseases or repairing damaged tissues. Among them, purines and their derivatives have shown the neuroprotection effects in the nervous system and garnered significant focus in the field of pharmaceutical development.
View Article and Find Full Text PDFEarly peripheral nerve impairments in type 1 diabetes are associated with cortical inhibition of ankle joint proprioceptive afference.
Clin Neurophysiol
March 2025
Faculty of Sport and Health Sciences, University of Jyväskylä, P.O. BOX 35, FI-40014 Jyväskylä, Finland; Center for Interdisciplinary Brain Research, University of Jyväskylä, PO Box 35, FI-40014 Jyväskylä, Finland.
Objective: Diabetic sensorimotor peripheral neuropathy (DSPN) is a common complication of type 1 diabetes mellitus (T1DM). However, it is still unclear how the cortical processing of proprioceptive afference is altered due to DSPN.
Methods: Cortical responses to right and left ankle joint rotations were recorded with magnetoencephalography and pooled together in 20 T1DM participants and 20 healthy controls for source space comparisons.
Proinflammatory cytokines, oxidative stress, and organ function as biomarkers of soman (GD) chronic neurotoxicity.
Sci Rep
March 2025
Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Organophosphate (OP) nerve agents, such as soman (GD), pose great risk to neurological health by inhibiting acetylcholinesterase, leading to seizures, epilepsy, and behavioral deficits. While acute treatment may alleviate immediate symptoms, the long-term consequences, particularly those involving neuroinflammation and systemic toxicity, remain poorly understood. This study used adult male and female Sprague Dawley rats to investigate the chronic effects of a single acute exposure to soman (132 µg/kg, s.
View Article and Find Full Text PDFConsiderations for tactile perceptual assessments: impact of arm dominance, nerve, location, and sex in young and older adults.
Exp Brain Res
March 2025
Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061, USA.
Purpose: Intact tactile perception is essential to successfully interact with objects. While tactile examinations exist for capturing tactile impairments, recent investigations underscore that these examinations remain insufficient, particularly for adults following a neurological injury. To inform the design of improved tactile assessments, this study comprehensively captures factors that can influence tactile perception in young and older adults who are neurologically intact.
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