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Maternal and pregnancy factors contributing to the association between area deprivation and infant mortality in England: a retrospective cohort study.
Lancet Reg Health Eur
December 2024
School of Health and Wellbeing, University of Glasgow, UK.
Background: Socioeconomic inequality in infant mortality in the UK is rising. This study aims to identify contributory maternal and pregnancy factors that can explain the known association between area deprivation and infant mortality.
Methods: A cohort study was conducted using Clinical Practice Research Datalink (CPRD) primary care data between 2004 and 2019 linked to the Index of Multiple Deprivation (IMD), and infant mortality from the Office for National Statistics death data.
Biology, function and structure of the calcium homeostasis modulator family.
J Physiol
October 2024
Cold Spring Harbor Laboratory, School of Biological Science at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Calcium homeostasis modulators (CALHMs) are the most recently discovered members of the large-pore channel family. They mediate the conductance of ions and larger molecules, such as ATP, and play critical roles in pathways related to Alzheimer's disease, neuroinflammation, neuromodulation, taste perception and innate immune responses. Since the inaugural report on CALHM1 in 2008, significant breakthroughs have revealed their biological roles, ion and ATP channel functions, and structures, positioning the field for further advancements.
View Article and Find Full Text PDFHeartfelt choices: The influence of cardiac phase on free-choice actions.
Psychophysiology
December 2024
Department of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.
Article Synopsis
- * Results indicated that participants were less likely to initiate volitional actions during the systole phase compared to diastole, suggesting that systole enhances inhibitory control over voluntary responses.
- * Further tests maintained the difference in voluntary action responses between systole and diastole, regardless of induced anxiety or increased heart rate, indicating that the heart's influence on decision-making operates independently of other physiological or psychological factors.
The 5th annual Beijing Health Data Science Summit, organized by the National Institute of Health Data Science at Peking University, recently concluded with resounding success. This year, the summit aimed to foster collaboration among researchers, practitioners, and stakeholders in the field of health data science to advance the use of data for better health outcomes. One significant highlight of this year's summit was the introduction of the Abstract Competition, organized by , a Science Partner Journal, which focused on the use of cutting-edge data science methodologies, particularly the application of artificial intelligence in the healthcare scenarios.
View Article and Find Full Text PDFHigh prevalence of severe pain is associated with low opioid availability in patients with advanced cancer: Combined database study and nationwide questionnaire survey in Japan.
Neuropsychopharmacol Rep
September 2024
Department of Pain and Palliative Medicines, The University of Tokyo Hospital, Tokyo, Japan.
Objectives: Opioid availability for the palliative care of patients with advanced cancer is increasing globally. However, opioid availability remains extremely low in Japan. We investigated whether pain is appropriately controlled by low-dose opioid prescriptions in patients with advanced cancer in Japan.
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