AI Article Synopsis
- The liver plays a key role in maintaining metabolic balance, which is essential for healthy brain function, especially as age-related neurodegenerative diseases impact elderly quality of life.
- Research has primarily focused on the effects of exercise on the aging brain, often overlooking how the liver and other peripheral organs influence brain health via blood circulation.
- This paper aims to explore the connection between the liver and brain, highlighting how metabolic processes can be influenced by exercise to potentially mitigate aging-related cognitive decline.
Article Abstract
Liver, an important regulator of metabolic homeostasis, is critical for healthy brain function. In particular, age-related neurodegenerative diseases seriously reduce the quality of life for the elderly. As population aging progresses rapidly, unraveling the mechanisms that effectively delay aging has become critical. Appropriate exercise is reported to improve aging-related cognitive impairment. Whereas current studies focused on exploring the effect of exercise on the aging brain itself, ignoring the persistent effects of peripheral organs on the brain through the blood circulation. The aim of this paper is to summarize the communication and aging processes of the liver and brain and to emphasize the metabolic mechanisms of the liver-brain axis about exercise ameliorating aging-related neurodegenerative diseases. A comprehensive understanding of the potential mechanisms about exercise ameliorating aging is critical for improving adaptation to age-related brain changes and formulating effective interventions against age-related cognitive decline.
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| http://dx.doi.org/10.1002/jcp.31287 | DOI Listing |
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