AI Article Synopsis
- - Cancer stem cells (CSCs) play a significant role in tumor growth and treatment resistance due to their abilities to self-renew and differentiate in multiple ways.
- - Recent research highlights iron metabolism as a crucial factor influencing the behavior and development of CSCs, impacting cancer prognosis and treatment outcomes.
- - The review discusses advancements in understanding iron's role in CSCs, challenges in conventional treatments targeting iron, and potential new therapies to combat resistant cancers.
Article Abstract
Cancer stem cells (CSCs), with their ability of self-renewal, unlimited proliferation, and multi-directional differentiation, contribute to tumorigenesis, metastasis, recurrence, and resistance to conventional therapy and immunotherapy. Eliminating CSCs has long been thought to prevent tumorigenesis. Although known to negatively impact tumor prognosis, research revealed the unexpected role of iron metabolism as a key regulator of CSCs. This review explores recent advances in iron metabolism in CSCs, conventional cancer therapies targeting iron biochemistry, therapeutic resistance in these cells, and potential treatment options that could overcome them. These findings provide important insights into therapeutic modalities against intractable cancers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11070091 | PMC |
| http://dx.doi.org/10.1186/s12935-024-03329-x | DOI Listing |
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