Objective: To identify whether histologically confirmed chorioamnionitis (hCAM) is associated with development of retinopathy of prematurity (ROP).
Study Design: We retrospectively analyzed 2 different cohorts. Cohort 1 was the national database of newborns in Japan born at ≤1500g or <32 weeks' gestation (January 2003 through April 2021, n = 38 013). Cohort 2 was babies born at <1500g from a single institution in Tsuchiura, Japan, (April 2015 through March 2018, n = 118).
Results: For Cohort1, after adjusting for potential confounders, stage III CAM (n = 5554) was associated with lower odds of severe ROP (stage ≥3 or required peripheral retinal ablation) by 14% (OR: 0.86; 95% CI: 0.78-0.94]. CAM of stage I (n = 3277) and II (n = 4319) was not associated with the risk of ROP. For Cohort 2, the odds of severe ROP were significantly reduced in moderate to severe hCAM groups (stage II, OR: 0.06, 95% CI: 0.05-0.82; stage III, OR: 0.10, 95% CI: 0.01-0.84). Neonates with funisitis, comorbidity of hCAM, and a finding of fetal inflammatory response had lower odds of severe ROP (OR: 0.11; 95% CI: 0.01-0.93).
Conclusions: After adjusting for confounders, severe hCAM with fetal inflammatory response was associated with reduced risk of ROP.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jpeds.2024.114085 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tetracaine versus proparacaine for retinopathy of prematurity exams.
Can J Ophthalmol
January 2025
Neonatal Intensive Care Unit, Surrey Memorial Hospital, Fraser Health Authority, British Columbia, Canada; Fraser Health Authority, British Columbia, Canada; University of British Columbia, Canada.
Retinopathy of prematurity (ROP) and diabetic retinopathy (DR) are ocular disorders in which a loss of retinal vasculature leads to ischemia followed by a compensatory neovascularization response. In mice, this is modeled using oxygen-induced retinopathy (OIR), whereby neonatal animals are transiently housed under hyperoxic conditions that result in central retina vessel regression and subsequent neovascularization. Using endothelial cell (EC)-specific gene deletion, we found that loss of two ETS-family transcription factors, ERG and FLI1, led to regression of OIR-induced neovascular vessels but failed to improve visual function, suggesting that relevant retinal damage occurs prior to and independently of neovascularization.
View Article and Find Full Text PDFIntraventricular Hemorrhage and Survival, Multimorbidity, and Neurodevelopment.
JAMA Netw Open
January 2025
Population Policy and Practice, Great Ormond Street UCL Institute of Child Health, London, United Kingdom.
Importance: Intraventricular hemorrhage (IVH) has proven to be a challenging and enduring complication of prematurity. However, its association with neurodevelopment across the spectrum of IVH severity, independent of prematurity, and in the context of contemporary care remains uncertain.
Objective: To evaluate national trends in IVH diagnosis and the association with survival and neurodevelopmental outcomes at 2 years of age.
Unlabelled: Hemodynamically significant patent ductus arteriosus (hs-PDA) in very low birth weight (VLBW) infants continues to be an issue of research regarding the timing of treatment and which would be the most appropriate drug.
Objective: To assess the outcome of prolonged treatment with paracetamol in the closure of hemodynamically significant patent ductus arteriosus in preterm newborns.
Patients And Method: Retrospective study in VLBW infants with echocardiographic and clinical diagnosis of hs-PDA who received treatment with intravenous paracetamol at 15 mg/kg every 6 hours for 6 days.
[High flow nasal cannula: is it a risk factor of bronchopulmonary dysplasia and retinopathy of premature?].
Andes Pediatr
August 2024
Servicio de Neonatologia, Complejo Asistencial Dr. Sótero del Río, Santiago, Chile.
Article Synopsis
- Observational studies show that using high-flow nasal cannula (HFNC) from 2013-2016 is linked to longer oxygen therapy duration, increased rates of bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP).
- The study aimed to analyze neonatal outcomes for very preterm newborns with HFNC between 2017-2021, using statistical methods to compare cases with controls based on weight and gestational age.
- Results indicated a significant rise in BPD and ROP in the HFNC group, alongside higher respiratory support, with logistic regression confirming HFNC use is associated with greater risks for both conditions, suggesting the need for a quality improvement program to enhance HFNC
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!