Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/brain/awae133 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impaired arbitration between reward-related decision-making strategies in Alcohol Users compared to Alcohol Non-Users: a computational modeling study.
NPP Digit Psychiatry Neurosci
January 2025
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY USA.
Article Synopsis
- Reinforcement learning contrasts model-free (habitual) and model-based (goal-directed) decision-making, with the latter being more common in high-reward scenarios.
- A study involving 81 participants revealed that frequent alcohol users lacked the ability to adjust their decision-making strategies based on reward levels, unlike non-users who displayed better model-based control in high-reward settings.
- Both groups were less risk-averse in high stakes, but alcohol users were generally more prone to risky decisions and showed impaired flexibility in adapting to changing reward conditions.
Humans rationally balance detailed and temporally abstract world models.
Commun Psychol
January 2025
Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
How do people model the world's dynamics to guide mental simulation and evaluate choices? One prominent approach, the Successor Representation (SR), takes advantage of temporal abstraction of future states: by aggregating trajectory predictions over multiple timesteps, the brain can avoid the costs of iterative, multi-step mental simulation. Human behavior broadly shows signatures of such temporal abstraction, but finer-grained characterization of individuals' strategies and their dynamic adjustment remains an open question. We developed a task to measure SR usage during dynamic, trial-by-trial learning.
View Article and Find Full Text PDFNegotiating a physically active life in tune with ageing: a grounded theory study of older persons' experiences of participating in high-intensity interval training.
BMC Geriatr
January 2025
Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Background: Physical activity and exercise are promoted worldwide as effective interventions for healthy ageing. Various exercise initiatives have been developed and evaluated for their efficacy and effectiveness among older populations. However, a deeper understanding of participants' experiences with these initiatives is crucial to foster long-term activity and exercise among older persons.
View Article and Find Full Text PDFInvasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2.
Nat Commun
January 2025
Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Glioblastoma (GBM) is a malignant brain tumor with diffuse infiltration. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 for confined migration through restricted space. Using live-cell imaging to track GBM cells negotiating microchannels, we reveal endocytic vesicle accumulation at cell front and filamentous actin assembly at cell rear in a polarized manner.
View Article and Find Full Text PDFIncidence of pressure injury in patients with moderate and severe traumatic brain injury: a systematic review.
BMJ Open
December 2024
Federal University of Sergipe, Sao Cristovao, Brazil
Background: Patients with moderate and severe traumatic brain injury (TBI) admitted to the intensive care unit (ICU) may develop pressure injury (PI) due to haemodynamic instability caused by the disease, lack of mobility in bed, as well as intense and prolonged compression in prominent bone areas.
Objective: The objective of this review is to assess the incidence and identify risk factor for the development of PI in patients with moderate and severe TBI admitted to the ICU.
Method: Searches were conducted in the PubMed, CINAHL, Scopus, Embase, Web of Science, Google Scholar, Trove and Open Grey databases, including all records found up to May 2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!