, commonly known as booklouse, is an important stored-product pest worldwide. Studies have demonstrated that booklices have developed resistance to several insecticides. In this study, an integument esterase gene, , with upregulated expression, was characterized in . Knockdown of resulted in a substantial increase in the booklice susceptibility to malathion. Overexpression of in significantly enhanced its malathion tolerance. Molecular modeling and docking analysis suggested potential interactions between LbEST-inte4 and malathion. When overexpressed in Sf9 cells, a notable elevation in esterase activity and malathion tolerance was observed. HPLC analysis indicated that the LbEST-inte4 enzyme could effectively degrade malathion. Taken together, the upregulated appears to contribute to malathion tolerance in by facilitating the depletion of malathion. This study elucidates the molecular mechanism underlying malathion detoxification and provides the foundations for the development of effective prevention and control measures against psocids.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jafc.4c02436 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multiple pesticide exposure and impaired glucose regulation in U.S. non-diabetic population.
Environ Pollut
December 2024
Department of Obstetrics and Gynecology, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, 210004, China. Electronic address:
Prediabetes is a serious metabolic disorder that is often overlooked and 70% of individuals with prediabetes would eventually develop type 2 diabetes. The diabetogenic effects of pesticides have been reported in toxicological studies but their association with prediabetes is rarely investigated. We aimed to evaluate the association between pesticide exposure and impaired glucose regulation (IGR), including prediabetes (defined as impaired fasting glucose [IFG] and/or impaired glucose tolerance [IGT]) and insulin resistance, in a general U.
View Article and Find Full Text PDFCharacterization of acetolactate synthase genes and resistance mechanisms of multiple herbicide resistant Lolium multiflorum.
Plant Physiol Biochem
November 2024
Institute of Plant Protection, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China; Key Laboratory of Integrated Pest Management on Crops in Southern Region of North China, Zhengzhou, 450002, China. Electronic address:
Article Synopsis
- * Analysis of the genetic mechanisms showed mutations in the acetolactate synthase (ALS) enzyme and various ALS gene copies contributing to this resistance.
- * The research also highlighted potential strategies to reverse resistance, including the use of specific inhibitors, which could help manage resistant weed populations better.
Overexpression of an Integument Esterase Gene Infers the Malathion Detoxification in (Psocoptera: Liposcelididae).
J Agric Food Chem
May 2024
Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400716, China.
, commonly known as booklouse, is an important stored-product pest worldwide. Studies have demonstrated that booklices have developed resistance to several insecticides. In this study, an integument esterase gene, , with upregulated expression, was characterized in .
View Article and Find Full Text PDFOrganophosphate pesticide residue impact on water quality and changes in macroinvertebrate community in an Afrotropical stream flowing through farmlands.
Environ Monit Assess
April 2024
Ecology and Environmental Biology Unit, Department of Animal Biology, Federal University of Technology Minna, Minna, P.M.B. 65, Nigeria.
River Chanchaga has experienced significant agricultural practices around its catchment, which involved the indiscriminate use of pesticides. However, residents of the study area are not well aware of the negative impact of pesticides on water quality and macroinvertebrates. In this study, the first report on the influence of organophosphate pesticide contamination on the abundance of the macroinvertebrate community was provided.
View Article and Find Full Text PDFNew findings on the risk of hypertension from organophosphorus exposure under different glycemic statuses: The key role of lipids?
Sci Total Environ
June 2024
Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address:
Background And Objective: Considering the widespread use of organophosphorus pesticides (OPs) and the global prevalence of hypertension (HTN), as well as studies indicating that different glycemic statuses may respond differently to the biological effects of OPs. Therefore, this study, based on the Henan rural cohort, aims to investigate the association between OPs exposure and HTN, and further explores whether lipids mediate these associations.
Methods: We measured the plasma levels of OPs in 2730 participants under different glycemic statuses using gas chromatography-triple quadrupole mass spectrometry (GC-MS/MS).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!