AI Article Synopsis
- Racialized economic segregation contributes to health disparities in breast cancer treatment and survival, revealing significant disparities based on race and economic status.
- A study of 27,459 women with metastatic breast cancer showed that those from less privileged areas experienced longer wait times for treatment and shorter overall survival compared to those from more privileged areas.
- Addressing racialized economic segregation through public investments is crucial to improving equity in cancer care and patient outcomes.
Article Abstract
Purpose: Racialized economic segregation, a form of structural racism, may drive persistent inequities among patients with breast cancer. We examined whether a composite area-level index of racialized economic segregation was associated with real-world treatment and survival in metastatic breast cancer (mBC).
Methods: We conducted a retrospective cohort study among adult women with mBC using a US nationwide electronic health record-derived de-identified database (2011-2022). Population-weighted quintiles of the index of concentration at the extremes were estimated using census tract data. To identify inequities in time to treatment initiation (TTI) and overall survival (OS), we employed Kaplan-Meier methods and estimated hazard ratios (HR) adjusted for clinical factors.
Results: The cohort included 27,459 patients. Compared with patients from the most privileged areas, those from the least privileged areas were disproportionately Black (36.9% vs. 2.6%) or Latinx (13.2% vs. 2.6%) and increasingly diagnosed with de novo mBC (33.6% vs. 28.9%). Those from the least privileged areas had longer median TTI than those from the most privileged areas (38 vs 31 days) and shorter median OS (29.7 vs 39.2 months). Multivariable-adjusted HR indicated less timely treatment initiation (HR 0.87, 95% CI 0.83, 0.91, p < 0.01) and worse OS (HR 1.19, 95% CI 1.13, 1.25, p < 0.01) among those from the least privileged areas compared to the most privileged areas.
Conclusion: Racialized economic segregation is a social determinant of health associated with treatment and survival inequities in mBC. Public investments directly addressing racialized economic segregation and other forms of structural racism are needed to reduce inequities in cancer care and outcomes.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11182814 | PMC |
| http://dx.doi.org/10.1007/s10549-024-07319-5 | DOI Listing |
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