AI Article Synopsis
- A study on a fungus sourced from cold-seep sediment, labeled CS-793, led to the discovery of 10 new sesquiterpenoids called pseuboyenes A-J.
- These compounds were analyzed using advanced techniques such as spectroscopy and X-ray crystallography, revealing unique structural features.
- Some of the compounds demonstrated notable antifungal properties, with minimum inhibitory concentrations (MICs) between 0.5 to 8 µg/mL, and one compound showed anti- activity at an EC value of 1.0 µg/mL.
Article Abstract
A chemical investigation of a cold-seep-sediment-derived fungus, CS-793, resulted in characterization of 10 novel bergamotene-derived sesquiterpenoids, pseuboyenes A-J (-). Their structures were elucidated by spectroscopic and X-ray crystallographic analyses as well as using the modified Mosher's method. Compound represents the first example of a -bergamotene containing a 6-oxobicyclo[3.2.1]octane nucleus adducted with a methyl lactate unit, while - involve a skeletal rearrangement from bergamotene. Compounds - showed significant antifungal activities against Penz. and with MICs ranging from 0.5 to 8 g/mL. Compound exhibited an anti- effect with an EC value of 1.0 g/mL.
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| http://dx.doi.org/10.1021/acs.jnatprod.3c01175 | DOI Listing |
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