AI Article Synopsis

  • The study investigates factors that positively predict clinical outcomes in acute ischemic stroke patients with large vessel occlusion after endovascular thrombectomy, with a focus on a 90-day follow-up.
  • It categorizes patients into favorable and unfavorable groups based on their modified Rankin Scale scores and uses statistical analyses to identify predictors, revealing that lower NIHSS scores, specific occlusions, and smaller infarct volumes correlate with better results.
  • A nomogram model was created to predict patient outcomes, achieving high accuracy with an area under the ROC curve of 0.848, indicating it could effectively guide clinical expectations for these patients.

Article Abstract

Purpose: To explore the positive predictors of the clinical outcome in acute ischemic stroke (AIS) patients with anterior circulation large vessel occlusion (ACLVO) after endovascular mechanical thrombectomy (EMT) at a 90-day follow-up, and to establish a nomogram model to predict the clinical outcome.

Materials And Methods: AIS patients with ACLVO detected by multimodal Computed Tomography imaging who underwent EMT were collected. Patients were divided into the favorable and the unfavorable groups according to the 90-day modified Rankin Scale (mRS) score. Univariate and multivariate analyses were performed to investigate predictors of the favorable outcome (mRS of 0-2). A nomogram model for predicting the clinical outcome after EMT was drawn, and the receiver operating characteristic (ROC) curve was used to evaluate its predictive value.

Results: Totally 105 patients including 65 patients in the favorable group and 40 in the unfavorable group were enrolled. Multivariate logistic regression analysis showed that admission National Institute of Health Stroke scale (NIHSS) score [0.858 (95% CI 0.778-0.947)], ACLVO at M2 [20.023 (95% CI 2.204-181.907)] and infarct core (IC) volume [0.943 (95% CI 0.917-0.969)] was positively correlated with favorable outcome. The accuracy of the nomogram model in predicting the outcome was 0.923 (95% CI 0.870-0.976), with a cutoff value of 119.6 points. The area under the ROC curve was 0.848 (95% CI 0.780-0.917; sensitivity, 79.7%; specificity, 90.0%).

Conclusion: A low Admission NIHSS score, ACLVO at M2, and a small IC volume were positive predictors for favorable outcome. The nomogram model may well predict the outcome in AIS patients with ACLVO after EMT.

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Source
http://dx.doi.org/10.1007/s11604-024-01583-7DOI Listing

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