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does not exert competitive exclusion on human corneocytes.
Microbiology (Reading)
January 2025
AIMES-Center for the Advancement of Integrated Medical and Engineering Sciences, Karolinska Institutet and KTH Royal Institute of Technology, SE-171 77 Stockholm, Sweden.
Human skin is our primary physical barrier and largest immune organ, and it also hosts a protective microbiota. Staphylococci are prominent members of the skin microbiota, including the ubiquitous coagulase-negative staphylococci (CoNS). The coagulase-positive is found as part of the microbiota, but it poses clinical concern due to its potential pathogenicity and antibiotic resistance.
View Article and Find Full Text PDFEvolving racial/ethnic disparities in AML survival in the novel therapy era.
Blood Adv
February 2025
Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA.
Little is known about the impact of recent advances in acute myeloid leukemia (AML) treatment on racial/ethnic disparities in survival outcomes. We performed a retrospective cohort study of patients with newly diagnosed AML using data from a nationwide electronic health record-derived deidentified database. Patients were categorized based on their diagnosis date relative to venetoclax approval, as pre-novel therapy era (Pre era; 2014-2018; n = 2998) or post-novel therapy era (Post era; 2019-2022; n = 2098).
View Article and Find Full Text PDFInnovative landscapes in intraperitoneal therapy of ovarian cancer.
Drug Deliv Transl Res
January 2025
Amrita School of Nanosciences & Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Epithelial ovarian cancer is the most prevalent gynecological malignancy, characterized by high mortality rates due to its late-stage diagnosis and frequent recurrence. The current standard of care for ovarian cancer is a combination of debulking surgery followed by the conventional mode of chemotherapy. Despite significant advances in therapeutic modalities, the overall survival rate of EOC continues to be poor, mainly because low concentrations of the chemotherapeutics reach the peritoneum, which is the primary site of ovarian cancer, leading to disease relapse.
View Article and Find Full Text PDFIn silico analysis of non-conventional gene targets for genetic interventions to enhance fatty acid production: a review.
Mol Biol Rep
January 2025
Department of Biological Sciences, Sunandan Divatia School of Science, NMIMS Deemed to be University, Vile Parle (West), Mumbai, 400056, India.
Since the 1990s, fatty acids (FA) have drawn significant industrial attention due to their diverse applications creating a demand for biological systems capable of producing high FA titers. While various strategies have been explored to achieve this, many of the conventional approaches rely on extensive genetic manipulations, which often result in strain instability, thus limiting its potential to yield better FA titers. Moreover, stresses such as pH, osmotic, and oxidative imbalances generated during FA production aggravate these challenges, further limiting FA titers.
View Article and Find Full Text PDFAdvanced Bismuth-Based Anode Materials for Efficient Potassium Storage: Structural Features, Storage Mechanisms and Modification Strategies.
Nanomicro Lett
January 2025
Department of Materials Science and Engineering, College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, People's Republic of China.
Potassium-ion batteries (PIBs) are considered as a promising energy storage system owing to its abundant potassium resources. As an important part of the battery composition, anode materials play a vital role in the future development of PIBs. Bismuth-based anode materials demonstrate great potential for storing potassium ions (K) due to their layered structure, high theoretical capacity based on the alloying reaction mechanism, and safe operating voltage.
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