AI Article Synopsis
- A new method for creating α-substituted sulfonyl amines involves using aryl aldehydes, primary sulfonamides, and (hetero)arenes.
- This synthesis is efficient and allows for the production of complex sulfonamide structures with high yields.
- The process uses cobalt-catalyzed C-H-activation to directly modify C(sp)-H bonds, providing a more efficient alternative to traditional synthesis methods like the Petasis or Mannich reactions.
Article Abstract
A three-component synthesis of α-substituted -sulfonyl amines from aryl aldehydes, primary sulfonamides, and (hetero)arenes is described. This transformation enables a straightforward and modular synthesis of highly substituted sulfonamide scaffolds in good yields. The direct functionalization of C(sp)-H bonds via cobalt-catalyzed C-H-activation offers an appealing and atom-economical alternative to classical methods for the synthesis of α-arylated amines such as the Petasis or Mannich-type reactions.
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| http://dx.doi.org/10.1021/acs.joc.4c00271 | DOI Listing |
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