AI Article Synopsis
- * Strong IgG activity was noted in microglia in areas like the corpus callosum and cerebellar white matter, and IgG stimulated these microglia to activate a specific immune response via the Syk pathway.
- * Mice lacking the ability to absorb maternal IgG showed issues with microglia and other brain cells, along with behavioral abnormalities, indicating that maternal IgG levels can influence brain development in offspring.
Article Abstract
Maternal immunoglobulin (Ig)G is present in breast milk and has been shown to contribute to the development of the immune system in infants. In contrast, maternal IgG has no known effect on early childhood brain development. We found maternal IgG immunoreactivity in microglia, which are resident macrophages of the central nervous system of the pup brain, peaking at postnatal one week. Strong IgG immunoreactivity was observed in microglia in the corpus callosum and cerebellar white matter. IgG stimulation of primary cultured microglia activated the type I interferon feedback loop by Syk. Analysis of neonatal Fc receptor knockout (FcRn KO) mice that could not take up IgG from their mothers revealed abnormalities in the proliferation and/or survival of microglia, oligodendrocytes, and some types of interneurons. Moreover, FcRn KO mice also exhibited abnormalities in social behavior and lower locomotor activity in their home cages. Thus, changes in the mother-derived IgG levels affect brain development in offsprings.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11064405 | PMC |
| http://dx.doi.org/10.1186/s12974-024-03100-z | DOI Listing |
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