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| http://dx.doi.org/10.1016/j.jaip.2024.04.044 | DOI Listing |
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Psychiatric disorders in children and adolescents with temporal lobe epilepsy: A narrative review.
Epilepsia Open
December 2024
University of Florence, Florence, Italy.
People with epilepsy (PWE) are at higher risk of psychiatric disorders (PD), disability, and reduced quality of life than the general population, especially in childhood and adolescence and when seizures originate from the temporal lobe. Temporal Lobe Epilepsy (TLE) is the most common type of focal epilepsy and can be due to structural abnormalities, or non-lesional causes, such as genetic variants. The prevalence of PD is approximately 20%-30% in people with epilepsy in general, and from 40% up to 80% in people with TLE.
View Article and Find Full Text PDFAdult Outcomes of Childhood Wheezing Phenotypes Are Associated with Early-Life Factors.
J Pers Med
December 2024
Respiratory Biomedical Research Centre, University Hospital Southampton, Southampton SO16 6YD, UK.
While the phenotypic diversity of childhood wheezing is well described, the subsequent life course of such phenotypes and their adult outcomes remain poorly understood. We hypothesized that different childhood wheezing phenotypes have varying longitudinal outcomes at age 26. We sought to identify factors associated with wheezing persistence, clinical remission, and new onset in adulthood.
View Article and Find Full Text PDFEarly-life microRNA signatures in cord blood associated with allergic rhinitis and asthma development.
J Allergy Clin Immunol
December 2024
Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Background: MicroRNAs (miRNAs) are involved in the biological regulation of asthma and allergies.
Objectives: To investigate the association between cord blood miRNAs and the development of allergic rhinitis and early childhood asthma.
Methods: miRNAs were sequenced from cord blood of subjects participating in the Vitamin D Antenatal Asthma Reduction Trial.
Exposure Profiles for the Long-Term Use of Disinfectants and Cleaning Products and Asthma.
Allergy
December 2024
Institute and Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, LMU Munich, Munich, Germany.
Background: Using disinfectants and cleaning products (DCPs) at home and work is known to influence both the onset and course of asthma, but most epidemiological studies did not consider the multiplicity and correlations of exposures to DCPs. We aimed to identify exposure profiles for the long-term weekly use of DCPs by latent class analysis (LCA) and assess their associations with asthma.
Methods: LCA was conducted on data from 1143 young adults initially recruited in the German centers of Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC) and followed up three times.
Neuroendocrine tumor discovered in a teenager following asthma misdiagnosis.
Arch Pediatr
December 2024
Sorbonne Université, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Trousseau, Service de Pneumologie Pédiatrique, Centre de Référence des Maladies Respiratoires Rares RespiRare, Paris, France; Sorbonne Université, Inserm U938, Centre de Recherche Saint-Antoine (CRSA), Paris, France. Electronic address:
Although relatively rare, neuroendocrine tumors (NETs) represent the most common type of endobronchial tumors in pediatric patients. Their clinical presentation lacks specificity, often leading to delayed diagnosis due to limited clinical suspicion. Mainly classified as low-grade malignant tumors (grade 1), they typically demonstrate favorable outcomes following surgical removal.
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