AI Article Synopsis
- Thyroid-stimulating hormone receptor autoantibodies (TRAbs) are important pathogenic antibodies used in the diagnosis and management of Graves' disease (GD), an autoimmune disorder that leads to hyperthyroidism.
- Advances in TRAb detection technology and commercial testing kits have made it a vital marker in identifying GD and its related conditions, such as Graves' ophthalmopathy.
- The article reviews various clinical assays for TRAb and highlights its importance in clinical practice.
Article Abstract
Thyroid-stimulating hormone receptor autoantibodies (TRAbs) play a crucial role as pathogenic antibodies in both the diagnosis and management of Graves' disease (GD). GD, an autoimmune disease resulting from a combination of genetic and environmental factors, is the most common cause of hyperthyroidism. With advancements in technology for TRAb detection and the availability of automated commercial kits, TRAb has become an essential clinical laboratory marker for the diagnosis of GD, as well as extra-thyroidal manifestations like Graves' ophthalmopathy (GO). This article provides a comprehensive review of TRAb, encompassing its clinical assays along with its significance in the clinical setting.
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| http://dx.doi.org/10.1016/j.cca.2024.119700 | DOI Listing |
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