AI Article Synopsis
- * Two female patients with both MG and LEMS saw little improvement from various immunotherapy options but experienced rapid recovery after receiving anti-CD19 CAR T cell therapy.
- * Following the treatment, both patients regained full mobility and returned to normal activities within two months, showcasing the potential of anti-CD19 CAR T cells in effectively treating complex neuroimmunological diseases.
Article Abstract
Myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) are autoimmune disorders affecting neuromuscular transmission. Their combined occurrence is rare, and treatment remains challenging. Two women diagnosed with concomitant MG/LEMS experienced severe, increasing disease activity despite multiple immunotherapies. Anti-CD19 chimeric antigen receptor (CAR) T cells have shown promise for treating autoimmune diseases. This report details the safe application of anti-CD19 CAR T cells for treating concomitant MG/LEMS. After CAR T cell therapy, both patients experienced rapid clinical recovery and regained full mobility. Deep B cell depletion and normalization of acetylcholine receptor and voltage-gated calcium channel N-type autoantibody levels paralleled major neurological responses. Within 2 months, both patients returned to everyday life, from wheelchair dependency to bicycling and mountain hiking, and remain stable at 6 and 4 months post-CAR T cell infusion, respectively. This report highlights the potential for anti-CD19 CAR T cells to achieve profound clinical effects in the treatment of neuroimmunological diseases.
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| http://dx.doi.org/10.1016/j.neuron.2024.04.014 | DOI Listing |
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