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Lateral hypopharyngectomy with laryngeal preservation reconstructed with inlay fascio-cutaneous free flaps: clinical and functional outcomes.
Acta Otorhinolaryngol Ital
December 2024
Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.
Article Synopsis
- Lateral hypopharyngectomy (LH) is a surgical method aimed at treating certain early-stage squamous cell carcinoma and other rare tumors, focusing on preserving the organ while managing complex cases of recurring cancer with various reconstruction techniques.* -
- A study reviewed patients who underwent LH between 2017 and 2023, looking at their clinical histories and outcomes; 71% had recurrent diseases, and most achieved negative surgical margins, with a successful swallowing rehabilitation for almost all patients post-surgery.* -
- The findings suggest that LH, combined with free flap reconstruction, can effectively and safely remove certain hypopharyngeal tumors while maintaining good functional and oncological results, evidenced by the survival of most patients after an average
Liposarcomas of the pharynx: A case report.
Am J Otolaryngol
June 2024
University Hospitals Department of Otolaryngology, Cleveland, OH, United States of America.
PD-L1 expression and CD8 positive lymphocytes in human neoplasms: A tissue microarray study on 11,838 tumor samples.
Cancer Biomark
February 2023
Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Background: Programmed death ligand 1 (PD-L1) is the target of immune checkpoint inhibitor therapies in a growing number of tumor types, but a unanimous picture on PD-L1 expression across cancer types is lacking.
Materials And Methods: We analyzed immunohistochemical PD-L1 expression in 11,838 samples from 118 human tumor types and its relationship with tumor infiltrating CD8 positive lymphocytes.
Results: At a cut-off level of 10% positive tumor cells, PD-L1 positivity was seen in 85 of 118 (72%) tumor types, including thymoma (100% positive), Hodgkin's lymphoma (93%), anaplastic thyroid carcinoma (76%), Kaposi sarcoma (71%), sarcomatoid urothelial carcinoma (71%), and squamous cell carcinoma of the penis (67%), cervix (65%), floor of the mouth (61%), the lung (53%), and pharynx (50%).
Nasopharyngeal low-grade papillary schneiderian carcinoma with cervical metastasis.
Auris Nasus Larynx
October 2023
Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Low-grade papillary Schneiderian carcinoma (LGPSC) is a rare and newly described type of cancer arising from the Schneiderian epithelium. Owing to cellular atypia, it is difficult to differentiate this type from other papillomas and malignancies. Although this condition remains unclear, it is associated with mortality and recurrence.
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