Herein, we demonstrate the first total synthesis of Macrotricolorin A and its enantiomer from the key intermediate which is accessible from two precursors phenol and resorcinol, by two different sequences. Macrotricolorin A possesses anti-inflammatory properties and is a novel diarylpropanoid. The first total synthesis of Macrotricolorin A was accomplished using simple reactions such as Williamson's etherification, Claisen-Schmidt condensation, reduction, and chiral resolution.
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| http://dx.doi.org/10.1080/14786419.2024.2341289 | DOI Listing |
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