A study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospital.

We investigated antibiotic resistance pattern in clinical bacterial pathogens isolated from in-patients and out-patients, and compared it with non-clinical bacterial isolates. 475 bacterial strains isolated from patients were examined for antibiotic resistance. spp. (148; 31.1%) were found to be the most prevalent, followed by (135; 28.4%), (74; 15.5%), (65; 13.6%), spp. (28; 5.8%), and spp. (25; 5.2%). Drug-resistant bacteria isolated were extended spectrum-β-lactamase . (8.8%), . (20%), metallo-β-lactamase . (14; 2.9%), erythromycin-inducing clindamycin resistant (7.4%), and methicillin-resistant species (21.6%). Pathogens belonging to the Enterobacteriaceae family were observed to undergo directional selection developing resistance against antibiotics ciprofloxacin, piperacillin-tazobactam, cefepime, and cefuroxime. Pathogens in the surgical ward exhibited higher levels of antibiotic resistance, while non-clinical . and . strains were more antibiotic-susceptible. Our research assisted in identifying the drugs that can be used to control infections caused by antimicrobial resistant bacteria in the population and in monitoring the prevalence of drug-resistant bacterial pathogens.