AI Article Synopsis
- - This study explores how SARS-CoV-2 proteins interact with human host proteins, revealing a network of 29 viral proteins connected to 2896 host proteins, with 176 specifically interacting with all viral proteins.
- - Key hub genes like EEF2 and RPS3, involved in critical processes like translation, were identified as central in the disease network, and their interactions suggest roles in COVID-19 and potential comorbidities.
- - The research identified 13 drug candidates that interact with these hub genes, highlighting estradiol as a promising option for repurposing to treat COVID-19, emphasizing the need for ongoing investigation into SARS-CoV-2's effects.
Article Abstract
The COVID-19 pandemic has become a significant global issue in terms of public health. While it is largely associated with respiratory complications, recent reports indicate that patients also experience neurological symptoms and other health issues. The objective of this study is to examine the network of protein-protein interactions (PPI) between SARS-CoV-2 proteins and human host proteins, pinpoint the central genes within this network implicated in disease pathology, and assess their viability as targets for drug development. The study adopts a network-based approach to construct a network of 29 SARS-CoV-2 proteins interacting with 2896 host proteins, with 176 host genes being identified as interacting genes with all the viral proteins. Gene ontology and pathway analysis of these host proteins revealed their role in biological processes such as translation, mRNA splicing, and ribosomal pathways. We further identified EEF2, RPS3, RPL9, RPS16, and RPL11 as the top 5 most connected hub genes in the disease-causing network, with significant interactions among each other. These hub genes were found to be involved in ribosomal pathways and cytoplasmic translation. Further a disease-gene interaction was also prepared to investigate the role of hub genes in other disorders and to understand the condition of comorbidity in COVID-19 patients. We also identified 13 drug molecules having interactions with all the hub genes, and estradiol emerged as the top potential drug target for the COVID-19 patients. Our study provides valuable insights using the protein-protein interaction network of SARS-CoV-2 proteins with host proteins and highlights the molecular basis of manifestation of COVID-19 and proposes drug for repurposing. As the pandemic continues to evolve, it is anticipated that investigating SARS-CoV-2 proteins will remain a critical area of focus for researchers globally, particularly in addressing potential challenges posed by specific SARS-CoV-2 variants in the future.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11059120 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e29967 | DOI Listing |
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