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Recent Applications of Pillararene-Inspired Water-Soluble Hosts.
Chemistry
January 2025
Shanghai University, Chemistry, 99 Shang-da Road, 200444, Shanghai, CHINA.
Pillararenes and their derivatives have emerged in supramolecular chemistry as unique macrocycles for applications in host-guest chemistry, materials science and biomimetics. Many variations have been conceived and synthesized in recent years and in this review, we relate progress in water-soluble versions: leaning towerarenes, extended-pillararenes, biphenarenes, helicarenes and octopusarenes. These are applied in targeted drug delivery, selective uptake and release of aromatic guests, fabrication of gold/silver and mesoporous silica nanoparticles, cell imaging, pollutant separation, biomedicine (e.
View Article and Find Full Text PDFEvaluation of the Body Burden of Short- and Medium-Chain Chlorinated Paraffins in the Blood Serum of Residents of the Czech Republic.
J Xenobiot
December 2024
Department of Food Analysis and Nutrition, Faculty of Food and Biochemical Technology, University of Chemistry and Technology Prague, Technicka 3, 166 28 Prague, Czech Republic.
Short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) are environmental contaminants known for their persistence and bioaccumulation in fatty tissues. SCCPs are considered potential carcinogens and endocrine disruptors, with similar effects expected for MCCPs. This study investigated the body burden of SCCPs and MCCPs in residents of two regions of the Czech Republic with different levels of industrial pollution.
View Article and Find Full Text PDFThe potential mechanisms underlying phthalate-induced hypospadias: a systematic review of rodent model studies.
Front Endocrinol (Lausanne)
December 2024
Department of Urology, Tianjin Children's Hospital/Tianjin University Children's Hospital, Tianjin, China.
Objectives: Maternal exposure to environmental endocrine disruptors, such as phthalates, during pregnancy is a significant risk factor for the development of hypospadias. By consolidating existing research on the mechanisms by which phthalates induce hypospadias in rodent models, this systematic review aims to organize and analyze the discovered mechanisms and their potential connections.
Methods: The study involved all articles that explored the mechanisms of phthalate-induced hypospadias using rodent models.
Plasticizer exposure in Germany from 1988 to 2022: Human biomonitoring data of 20 plasticizers from the German Environmental Specimen Bank.
Environ Int
December 2024
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University-Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. Electronic address:
The German Environmental Specimen Bank (ESB) annually archives 24-h urine samples since the early 1980s. In this study, we analyzed 420 of these samples from the years 2014 to 2022 for metabolites of 18 phthalates and two substitutes. We merged the new data with the data from previous measurement campaigns to a combined dataset of 1825 samples covering a 35-year period from 1988 to 2022 to investigate time trends, calculate daily intakes and perform an anti-androgenic mixture risk assessment.
View Article and Find Full Text PDFNanomedicine mediated thyroid cancer diagnosis and treatment: an approach from generalized to personalized medicine.
Discov Oncol
December 2024
Department of Medical Oncology Laboratory, All India Institute of Medical Sciences, New Delhi, India.
Thyroid cancer (TC) being the common endocrine malignancy is glooming steadily due to its poor prognosis. The treatment strategies of surgery, radiotherapy, and conventional chemotherapy are providing unsatisfactory output. However, combination therapy can negotiate the worse prognosis to the better, where chemoradiotherapy, radiotherapy with surgery, or dual chemotherapeutic drugs are being glorified.
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