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The Application of Traditional Chinese Medicine-Derived Formulations in Cancer Immunotherapy: A Review.
Cancer Manag Res
January 2025
School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People's Republic of China.
Background: Cancer immunotherapy is an advanced therapeutic approach that harnesses the body's immune system to target and eliminate tumor cells. Traditional Chinese medicine (TCM), with a history rooted in centuries of clinical practice, plays a crucial role in enhancing immune responses, alleviating cancer-related symptoms, and reducing the risks of infections and complications in cancer patients.
Methodology: This review systematically examines the current literature on TCM-based formulations in cancer immunotherapy.
[Safety and efficacy assessments using human iPS cell-derived cardiomyocytes].
Nihon Yakurigaku Zasshi
January 2025
The delay and loss of drugs are serious problems in Japan. To overcome this issue, it is important to strengthen drug development capabilities. For drug development, the establishment and advancement of non-clinical testing methods are necessary for safe and effective clinical trials.
View Article and Find Full Text PDFPreliminary evaluation of a novel PSMA-targeting radiopharmaceutical [Ga]Ga/[Lu]Lu-NYM032 for theranostic use in prostate cancer.
Eur J Nucl Med Mol Imaging
January 2025
Department of Nuclear Medicine, Affiliated Hospital of Jiangnan University, No. 1000, Hefeng Road, Wuxi, Jiangsu Province, 214000, China.
Article Synopsis
- A new theranostic radiopharmaceutical, [Ga]Ga/[Lu]Lu-NYM032, was developed to target prostate-specific membrane antigen (PSMA) for diagnosing and treating prostate cancer (PCa).
- In preclinical studies, [Ga]Ga-NYM032 showed high specificity and uptake in PSMA-positive tumors, outperforming a comparator in detecting bone and lymph node metastases.
- The therapeutic component, [Lu]Lu-NYM032, demonstrated effectiveness in inhibiting tumor growth in animal models, with larger doses leading to significantly smaller tumor sizes.
Cancer Organoids as reliable disease models to drive clinical development of novel therapies.
J Exp Clin Cancer Res
December 2024
Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
On September 23-24 (2024) the 6th Workshop IRE on Translational Oncology, titled "Cancer Organoids as Reliable Disease Models to Drive Clinical Development of Novel Therapies," took place at the IRCCS Regina Elena Cancer Institute in Rome. This prominent international conference focused on tumor organoids, bringing together leading experts from around the world.A central challenge in precision oncology is modeling the dynamic tumor ecosystem, which encompasses numerous elements that evolve spatially and temporally.
View Article and Find Full Text PDFStrengthening autonomy in mental health care through a relational approach.
Nat Ment Health
November 2024
Bioethics Program, FLACSO Argentina, Buenos Aires, Argentina.
Respect for autonomy is foundational to all types of clinical care, and receiving mental health care places people in a vulnerable situation that has a direct impact on their ability to live as they choose, making concerns about autonomy central. The classical understanding of personal autonomy, which still influences medical guidelines, is based on an individualistic framework and is inadequate for ethical mental health care. The goal of this Comment is to articulate why the relational autonomy model, developed in feminist bioethics, is a necessary approach for the mental health field.
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