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Dronabinol Is Not a Game Changer in Pediatric Palliative Care: Results from a Retrospective Study.
Children (Basel)
August 2024
Pediatric Palliative Care Centre, Children's and Adolescents' Hospital Datteln, 45711 Datteln, Germany.
Background/objectives: Patients with life-limiting conditions (LLCs) often suffer from restlessness, spasticity, pain, and seizures. Dronabinol (DRB) may have a relieving effect; however, data on the effectiveness of DRB in children with LLCs are limited to outpatients. The aim of this study was to assess the efficacy and safety of DRB.
View Article and Find Full Text PDFInpatient dronabinol utilisation: an institutional retrospective study to determine prevalence and indications for clinical application.
Br J Anaesth
July 2024
Department of Anesthesiology, Critical Care & Pain Management, Hospital for Special Surgery, New York, NY, USA; Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA; Pain Prevention Research Center, Hospital for Special Surgery, New York, NY, USA; HSS Research Institute, New York, NY, USA. Electronic address:
Exploratory Growth Mixture Modeling of Cannabis-Withdrawal Syndrome Trajectories of Adult Pure Cannabis Dependents During Detoxification: Two Subtypes?
J Psychoactive Drugs
October 2024
Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, EvangelIsches Krankenhaus Castrop-Rauxel, Academic Teaching Hospital of the University Duisburg-Essen, Castrop-Rauxel, Germany and Head of PedScience Research Institute. Datteln, Germany and Doctor rerum medicarum, University Duisburg-Essen; Essen, Germany.
As clinical studies about subtypes of the cannabis withdrawal syndrome (CWS) are scant, we performed a re-analysis of longitudinal data with German adult cannabis-users seeking inpatient cannabis detoxification-treatment. Sixty-seven cannabis-dependents without active comorbidity were included for growth-mixture-analysis (GMM) of their CWS-severity-trajectories during a scheduled 24-day detox-treatment. As of treatment-day 12, thirty-six (53.
View Article and Find Full Text PDF[Tetrahydrocannabinol (THC) in patients with fibromyalgia syndrome (FMS) : A retrospective study of changes in pain, psychometric variables, and analgesic consumption during inpatient interdisciplinary multimodal pain therapy (IMPT)].
Schmerz
August 2024
Fachbereich Psychodiabetologie, Diabetes-Klinik Bad Mergentheim, Theodor-Klotzbücher-Str. 12, 97980, Bad Mergentheim, Deutschland.
Background: Since March 1, 2017, medical cannabis (MC) can be prescribed nationwide in Germany. To date, there have been a number of qualitatively different studies on the effectiveness of MC in fibromyalgia syndrome (FMS).
Objective: The aim of the study was to investigate the effectiveness of THC in the course of interdisciplinary multimodal pain therapy (IMPT) on pain and several psychometric variables.
Smoked cannabis reduces peak cocaine plasma levels and subjective effects in a controlled drug administration study of polysubstance use in men.
Drug Alcohol Depend
February 2023
UCLA Center for Cannabis and Cannabinoids, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, USA; Columbia University Irving Medical Center, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY, USA; Department of Anesthesiology and Perioperative Medicine, David Geffen School of Medicine University of California, Los Angeles, USA. Electronic address:
Background: Despite the high prevalence of polysubstance use, outcomes and potential risks associated with common drug combinations are not well characterized. Many individuals who use cocaine also use cannabis, yet little is known about how interactions between the two drugs might contribute to continued co-use.
Methods: The aim of this double-blind, placebo-controlled study was to determine the physiological and subjective effects of smoked cannabis with smoked cocaine, to identify variables that may contribute to the continued use of this drug combination.
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