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Epidemics of signification and global health policy: From the end of AIDS to the end of scale-up of the global AIDS response.
Glob Public Health
January 2024
Associação Brasileira Interdisciplinar de AIDS (ABIA), Rio de Janeiro, Brazil.
Over the past four and a half decades, the history of the HIV and AIDS pandemic has gone through a number of different phases, which can be thought of as distinct waves in terms of the social and political response that the pandemic has generated. Over the course of this history, there have been important battles over the meanings and interpretations that the response to the pandemic has produced. But especially over the past decade, there seems to be a growing disconnect between claims of success made by many global health agencies and policymakers and the empirical reality that these claims cover up.
View Article and Find Full Text PDFHIV Vaccine Development at a Crossroads: New B and T Cell Approaches.
Vaccines (Basel)
September 2024
Division of Infectious Diseases and Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Despite rigorous scientific efforts over the forty years since the onset of the global HIV pandemic, a safe and effective HIV-1 vaccine remains elusive. The challenges of HIV vaccine development have proven immense, in large part due to the tremendous sequence diversity of HIV and its ability to escape from antiviral adaptive immune responses. In recent years, several phase 3 efficacy trials have been conducted, testing a similar hypothesis, e.
View Article and Find Full Text PDFAt a crossroads: The crucial role of pharmacists in healthcare teams to end the HIV epidemic.
Am J Health Syst Pharm
September 2024
Department of Clinical Pharmacy, University of California San Francisco, School of Pharmacy, San Francisco, CA, USA.
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
View Article and Find Full Text PDFExtracellular vesicle isolation methods identify distinct HIV-1 particles released from chronically infected T-cells.
J Extracell Vesicles
July 2024
Laboratory of Molecular Virology, School of System Biology, George Mason University, Manassas, Virginia, USA.
The current study analyzed the intersecting biophysical, biochemical, and functional properties of extracellular particles (EPs) with the human immunodeficiency virus type-1 (HIV-1) beyond the currently accepted size range for HIV-1. We isolated five fractions (Frac-A through Frac-E) from HIV-infected cells by sequential differential ultracentrifugation (DUC). All fractions showed a heterogeneous size distribution with median particle sizes greater than 100 nm for Frac-A through Frac-D but not for Frac-E, which contained small EPs with an average size well below 50 nm.
View Article and Find Full Text PDFForty Years of HIV Research in French Guiana: Comprehend to Combat.
Pathogens
May 2024
Département Formation Recherche en Santé, Université de Guyane, 97300 Cayenne, French Guiana.
The drivers of the HIV epidemic, the viruses, the opportunistic infections, the attitudes and the resources allocated to the fight against HIV/AIDS, vary substantially across countries. French Guiana, at the crossroads between Amazonian South America and the Caribbean, constitutes a singular context with poor populations and rich country health funding, which has allowed researchers to gather lots of information on the particulars of our epidemic. We aimed to focus on the little known story of forty years of HIV research in French Guiana and emphasize how local research intertwined with public health action has yielded continuous progress, despite the difficult social conditions of the affected population.
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