Water-Mediated On-Demand Detachable Solid-State Adhesive of Porous Hydroxyapatite for Internal Organ Retractions.

Adv Healthc Mater

Department of Biomaterials, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama, 700-8558, Japan.

Published: July 2024

AI Article Synopsis

  • Novel adhesives made from porous hydroxyapatite (HAp) ceramics provide a new method for surgical procedures involving biological tissues.
  • These adhesives work by allowing water to move from soft tissues into their porous structure, which helps them effectively attach to different tissue types under various hydration conditions.
  • Demonstrated during surgeries on porcine livers, these HAp adhesive devices show strong holding capabilities and can be easily detached when needed, indicating their potential use as internal organ retractors in laparoscopic surgeries.

Article Abstract

Novel adhesives for biological tissues offer an advanced surgical approach. Here, the authors report the development and application of solid-state adhesives consisting of porous hydroxyapatite (HAp) biocompatible ceramics as novel internal organ retractors. The operational principles of the porous solid-state adhesives are experimentally established in terms of water migration from biological soft tissues into the pores of the adhesives, and their performance is evaluated on several soft tissues with different hydration states. As an example of practical medical utility, HAp adhesive devices demonstrate the holding ability of porcine livers and on-demand detachability in vivo, showing great potential as internal organ retractors in laparoscopic surgery.

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Source
http://dx.doi.org/10.1002/adhm.202304616DOI Listing

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