Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00467-024-06390-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multi-stage optimization framework for synergetic grey-green infrastructure in response to long-term climate variability based on shared socio-economic pathways.
Water Res
January 2025
College of Architecture and Urban Planning, Tongji University, Shanghai 200093, China. Electronic address:
Global climate change and rapid urbanization have increasingly intensified extreme rainfall events and surface runoff, posing significant challenges to urban hydrological security. Synergetic Grey-Green Infrastructure (SGGI) has been widely applied to enhance stormwater management in urban areas. However, current research primarily focused on optimizing and evaluating either grey infrastructure (GREI) or green infrastructure (GI) under single rainfall event, neglecting the non-stationary impacts of long-term climate change on infrastructure performance.
View Article and Find Full Text PDFRoutine childhood rabies pre-exposure prophylaxis can be cost effective in low- and middle-income countries.
Vaccine
January 2025
Jenner Institute, Old Road Campus Research Building, University of Oxford, Oxford OX3 7DQ, UK.
Background: Pre-exposure prophylactic rabies vaccination (PrEP) is advised for travellers to countries with high rabies incidence, but rarely available for local residents. Some studies suggest poor cost-effectiveness of PrEP in such settings, but have generally focused upon post-exposure prophylaxis (PEP) cost savings as the main benefit of PrEP, without considering lives saved by PrEP efficacy.
Methods: We compared incremental cost-effectiveness ratios (ICERs) of use of rabies PrEP, against an alternative of using only PEP, by adapting a decision-tree model previously used to inform Gavi's investment in rabies PEP.
The Cost-Effectiveness of CDK4/6 Inhibitors in Treating HR+/HER2- Metastatic Breast Cancer Patients in the USA: When Non-medication Expenses are Considered.
Clin Drug Investig
January 2025
Department of Public Health Sciences, University of Virginia, 560 Ray C Hunt Dr., Room 2107, Charlottesville, VA, USA.
Background And Objective: Cyclin-dependent kinase (CDK)4/6 inhibitors in combination with endocrine therapy (ET) significantly enhance progression-free survival and overall survival in patients diagnosed with HR+/HER2- metastatic breast cancer (MBC). However, they are highly expensive, and their economic impact has not been fully evaluated. This is a retrospective secondary analysis evaluating the cost effectiveness of these drugs, differentiating between medication-related and non-medication costs from a healthcare perspective.
View Article and Find Full Text PDFOutpatient surgical management of head and neck keratinocyte cancers in a regional centre: an updated analysis of costs and outcomes.
ANZ J Surg
January 2025
Otolaryngology Head and Neck Surgery, Darling Downs Hospital and Health Service, Toowoomba, Queensland, Australia.
Background: Australia has the highest global incidence of keratinocyte cancer. Surgically managing keratinocyte cancers in regional Australia presents geographic and economic challenges, which necessitate cost-effective resource allocation. Previous work has outlined the cost benefit for outpatient day surgical excision of head and neck skin lesions that can be closed primarily.
View Article and Find Full Text PDFOptimised Workflows for Profiling the Metabolic Fluxes in Suspension vs. Adherent Cancer Cells via Seahorse Technology.
Int J Mol Sci
December 2024
Laboratory of Preclinical and Translational Research, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero in Vulture, 85028 Potenza, Italy.
Oxidative phosphorylation and glycolysis are the main ATP-generating pathways in cell metabolism. The balance between these two pathways is frequently altered to carry out cell-specific activities in response to stimuli involving activation, proliferation, or differentiation. Despite being a useful tool for researching metabolic profiles in real time in relatively small numbers of cancer cells, the main Agilent Seahorse XF Pro Analyzer (Agilent Technologies, Santa Clara, CA, USA) guideline is currently not fully detailed in the distinction between suspensions vs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!