AI Article Synopsis
- Periodontitis is a chronic inflammatory condition affecting the tissues supporting teeth, potentially leading to tooth loss if not treated.
- Current treatments involve mechanical removal of bacteria and the use of antimicrobial and anti-inflammatory drugs, which are often delivered locally for effectiveness.
- Oleogels show promise in drug delivery for periodontitis due to their advantageous properties; however, more research is needed to confirm their clinical effectiveness in dentistry.
Article Abstract
Periodontitis is the chronic inflammation of tooth-supporting tissues that leads to loss of tooth support if untreated. Conventional therapy for periodontitis (mechanical removal of microbial biofilm and oral hygiene enforcement) is augmented by anti-microbial and anti-inflammatory drugs. These drugs are frequently delivered locally into the periodontal pocket for maximum efficiency and minimum adverse effects. The potential of oleogels for periodontal drug delivery has been discussed and further, the future scope of oleogel-based drug delivery systems in dentistry. An oleogel-based local drug delivery system offers several advantages over other systems. Superior mechanical properties (firmness and compressibility), muco-adhesion, shear thinning, thixotropy, controlled drug release and the ability to incorporate water-insoluble drugs clearly distinguish and highlight the potential of oleogels as periodontal local drug delivery systems. Bigels can combine the qualities of both hydrogels and oleogels to provide a more promising option for drug delivery. However, there is limited evidence concerning oleogels as local drug delivery agents in periodontics. Further studies are needed to discern the clinical efficacy of oleogel-based drug delivery systems.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058454 | PMC |
| http://dx.doi.org/10.12688/f1000research.140173.1 | DOI Listing |
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