AI Article Synopsis
- Scientists studied fungi from plants to find out if they can help create useful substances.
- They tested three types of fungi from different parts of the plants and mixed them with various chemicals to see how they would grow.
- The results showed that certain chemicals made the fungi produce compounds that could potentially fight breast cancer cells.
Article Abstract
This study aimed to discover the potential of -derived fungal endophytes as a prospective source of bioactive metabolites. In the present study, three different strains of fungal endophyte were isolated from leaves L, roots T and stems St of to explore their biological and chemical diversity. These isolated fungi were exposed to different fermentation conditions by adding various chemical elicitors to their solid fermentation media. According to LC-HRESIMS-based metabolomics and multivariate analysis, each chemical treatment had a different effect on the chemical profiles of the fungi. Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) proposed several compounds with anticancer action against MCF-7 (a human breast cancer cell line) and MDA-MB-231 (a human epithelial breast cancer cell line).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11059938 | PMC |
| http://dx.doi.org/10.1039/d4ra00790e | DOI Listing |
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