Although the additive manufacturing (AM) market continues to grow, industries face barriers to AM adoption due to a shortage of skilled designers in the workforce that can apply AM effectively to meet this demand. This shortage is attributed to the high cost and infrastructural requirements of introducing high- barrier-to-entry AM processes such as powder bed fusion (PBF) into in-person learning environments. To meet the demands for a skilled AM workforce, it is important to explore other mediums of AM education, such as computer-aided instruction (CAI) and virtual reality (VR), which can increase access to hands-on learning experiences for inaccessible AM processes. However, limited work compares virtual and physical AM instruction or explores how the differences in immersion and presence between mediums can affect the knowledge gained and the mental effort exerted when learning about different AM processes. To address this gap in the literature, this research evaluates the use of CAI, VR, and in-person instruction in AM process education when learning about material extrusion (ME) and PBF. Our findings show that the differences in immersion and presence between CAI, VR, and in-person instruction do not have a statistically significant effect when learning about ME, but do have a significant effect when learning about PBF. Specifically, we found that VR generally yields equivalent effects in knowledge gain and cognitive load to in-person PBF education while offering advantages in both metrics over CAI learning. The findings from this work thus have significant implications for using VR as an alternative to in-person training to improve designer development in process-centric AM education of typically high-barrier-to-entry AM processes.
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http://dx.doi.org/10.1089/3dp.2022.0180 | DOI Listing |
J Mol Evol
January 2025
Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, Netherlands.
The major histocompatibility complex (MHC) is a cluster of functionally related genes encoding proteins which, among other functions, mediate immune system activation. While the MHC of many vertebrates has been extensively studied, less is known about the amphibian MHC. This represents an important knowledge gap because amphibians mark the evolutionary transition from an aquatic to a terrestrial lifestyle and often maintain a biphasic lifestyle.
View Article and Find Full Text PDFBiomark Res
January 2025
Department of Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA.
FMS-like tyrosine kinase 3 (FLT3) genetic variants are commonly seen in high-grade myeloid neoplasms and are typically gain-of-function mutations associated with a proliferative disease phenotype. Inactivating FLT3 variants have been less frequently described in non-malignant, autoimmune disorders and are uncommon in aplastic anemia (AA). Herein, we report the first to our knowledge, and unusual case of a germline, gain-of-function, FLT3 variant in a patient with severe AA treated successfully with immunosuppressive therapy.
View Article and Find Full Text PDFPharmaceutics
November 2024
Faculty of Medicine, Institute of Pharmacy, University of Tartu, Nooruse 1, 50411 Tartu, Estonia.
: An automated extrusion-based material deposition is a contemporary and rapid method for pharmaceutical dose-dispensing and preparing (printing) individualized solid dosage forms. The aim of this study was to investigate and gain knowledge of the feasibility of automated extrusion-based material deposition technology in preparing customized prednisolone (PRD)-loaded gel tablets for veterinary applications (primarily for dogs and cats). : The PRD loads of the extrusion-based deposited gel tablets were 0.
View Article and Find Full Text PDFNutrients
December 2024
Centers for Disease Control and Prevention (CDC), 4770 Buford Highway, NE, Atlanta, GA 30341, USA.
Background: Frequent consumption of sugar-sweetened beverages (SSB) is associated with an increased risk of some health outcomes.
Objective: We investigated the relationships between knowledge of health risks related to SSB and SSB intake among adults.
Methods: This cross-sectional study utilized data from the 2021 SummerStyles survey.
Materials (Basel)
December 2024
Chair of Paper Technology and Mechanical Process Engineering, Technical University of Darmstadt, 64289 Darmstadt, Germany.
This paper proposes a novel approach to represent the geometry of the corrugated board profile during compression using graphs. Graphs are lighter than images, and the computational time of compression analysis is then significantly reduced compared to using the original image data for the same analysis. The main goal of using such graphs is to gain more knowledge about the mechanical behavior of corrugated boards under compression compared to the current load-deformation curve approach.
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