AI Article Synopsis
- * Lymphatic endothelial cells (LECs) and blood endothelial cells (BECs) are crucial not just for structural support but also for processes like blood vessel formation (angiogenesis), lymph vessel formation (lymphangiogenesis), and immune response modulation.
- * The review focuses on the intricate interactions between LECs, BECs, and tumor cells, highlighting their roles in HCC and proposing future research and treatment avenues based on the immune functions of these endothelial cells.
Article Abstract
The tumor microenvironment is a complex network of cells, extracellular matrix, and signaling molecules that plays a critical role in tumor progression and metastasis. Lymphatic and blood vessels are major routes for solid tumor metastasis and essential parts of tumor drainage conduits. However, recent studies have shown that lymphatic endothelial cells (LECs) and blood endothelial cells (BECs) also play multifaceted roles in the tumor microenvironment beyond their structural functions, particularly in hepatocellular carcinoma (HCC). This comprehensive review summarizes the diverse roles played by LECs and BECs in HCC, including their involvement in angiogenesis, immune modulation, lymphangiogenesis, and metastasis. By providing a detailed account of the complex interplay between LECs, BECs, and tumor cells, this review aims to shed light on future research directions regarding the immune regulatory function of LECs and potential therapeutic targets for HCC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11056903 | PMC |
| http://dx.doi.org/10.4254/wjh.v16.i4.537 | DOI Listing |
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