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Molecular glues and induced proximity: An evolution of tools and discovery. | LitMetric

Molecular glues and induced proximity: An evolution of tools and discovery.

Cell Chem Biol

Department of Chemistry, Stanford University, Stanford, CA, USA; Sarafan ChEM-H, Stanford University, Stanford, CA, USA. Electronic address:

Published: June 2024

AI Article Synopsis

Article Abstract

Small molecule molecular glues can nucleate protein complexes and rewire interactomes. Molecular glues are widely used as probes for understanding functional proximity at a systems level, and the potential to instigate event-driven pharmacology has motivated their application as therapeutics. Despite advantages such as cell permeability and the potential for low off-target activity, glues are still rare when compared to canonical inhibitors in therapeutic development. Their often simple structure and specific ability to reshape protein-protein interactions pose several challenges for widespread, designer applications. Molecular glue discovery and design campaigns can find inspiration from the fields of synthetic biology and biophysics to mine chemical libraries for glue-like molecules.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chembiol.2024.04.001DOI Listing

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